PMID- 18550280
OWN - NLM
STAT- MEDLINE
DCOM- 20080915
LR  - 20240312
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 440
IP  - 2
DP  - 2008 Aug 1
TI  - Characterization of trkB immunoreactive cells in the intermediolateral cell 
      column of the rat spinal cord.
PG  - 103-8
LID - 10.1016/j.neulet.2008.05.057 [doi]
AB  - The objective of the present study was to characterize the trkB receptor 
      immunoreactive (-ir) cells in the intermediolateral cell column (IML) of the 
      upper thoracic spinal cord. Small trkB-ir cells (area=56.1+/-4.4 microm(2)) 
      observed in the IML showed characteristics of oligodendrocytes and were 
      frequently observed in close apposition to choline acetyltransferase (ChAT)-ir 
      cell bodies. Large trkB-ir cells (area=209.3+/-25.2 microm(2)) showed 
      immunoreactivity for the neuronal marker NeuN, indicating their neuronal 
      phenotype, as well as for ChAT, a marker for preganglionic neurons. TrkB and ChAT 
      were co-localized in IML neurons primarily in cases that had received in vivo 
      administration of nerve growth factor (NGF). These findings reveal two different 
      cell types, oligodendrocytes and neurons, in the IML of the spinal cord that show 
      trkB immunoreactivity, suggesting their regulation by brain derived neurotrophic 
      factor (BDNF) and/or neurotrophin-4 (NT-4). In addition, there is evidence that 
      NGF may play a role in the regulation of trkB-ir preganglionic neurons in the 
      IML.
FAU - McCartney, Annemarie M
AU  - McCartney AM
AD  - Center for Neuroscience and Behavior, Department of Zoology, Miami University, 
      280 Pearson Hall, Oxford, OH 45056, United States.
FAU - Abejuela, Vanessa L
AU  - Abejuela VL
FAU - Isaacson, Lori G
AU  - Isaacson LG
LA  - eng
GR  - R15 NS051206/NS/NINDS NIH HHS/United States
GR  - R15 NS051206-01/NS/NINDS NIH HHS/United States
GR  - NS051206/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080521
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - EC 2.3.1.6 (Choline O-Acetyltransferase)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/analysis
MH  - Choline O-Acetyltransferase/metabolism
MH  - Immunohistochemistry
MH  - Injections, Intraventricular
MH  - Microscopy, Confocal
MH  - Nerve Growth Factor/administration & dosage/pharmacology
MH  - Nerve Growth Factors/analysis
MH  - Neurons/cytology/drug effects/*metabolism
MH  - Oligodendroglia/cytology/drug effects/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/*metabolism
MH  - Spinal Cord/cytology/drug effects/*metabolism
PMC - PMC2525737
MID - NIHMS57953
EDAT- 2008/06/14 09:00
MHDA- 2008/09/16 09:00
PMCR- 2009/08/01
CRDT- 2008/06/14 09:00
PHST- 2008/03/21 00:00 [received]
PHST- 2008/05/09 00:00 [revised]
PHST- 2008/05/10 00:00 [accepted]
PHST- 2008/06/14 09:00 [pubmed]
PHST- 2008/09/16 09:00 [medline]
PHST- 2008/06/14 09:00 [entrez]
PHST- 2009/08/01 00:00 [pmc-release]
AID - S0304-3940(08)00658-7 [pii]
AID - 10.1016/j.neulet.2008.05.057 [doi]
PST - ppublish
SO  - Neurosci Lett. 2008 Aug 1;440(2):103-8. doi: 10.1016/j.neulet.2008.05.057. Epub 
      2008 May 21.