PMID- 18550446
OWN - NLM
STAT- MEDLINE
DCOM- 20080925
LR  - 20131121
IS  - 1532-0456 (Print)
IS  - 1532-0456 (Linking)
VI  - 148
IP  - 2
DP  - 2008 Aug
TI  - Maternally derived testosterone and 17beta-estradiol in the eggs of 
      Arctic-breeding glaucous gulls in relation to persistent organic pollutants.
PG  - 143-51
LID - 10.1016/j.cbpc.2008.04.010 [doi]
AB  - It is largely unknown if and how persistent organic pollutants (POPs) affect the 
      transfer of maternal hormones to eggs. This occurs despite an increasing number 
      of studies relating environmental conditions experienced by female birds at the 
      time of egg formation to maternal hormonal effects. Here we report the 
      concentrations of maternal testosterone, 17beta-estradiol and major classes of 
      POPs (organochlorines, brominated flame retardants and metabolically-derived 
      products) in the yolk of unincubated, third-laid eggs of the glaucous gull (Larus 
      hyperboreus), a top-predator in the Arctic marine environment. Controlled for 
      seasonal and local variation, positive correlations were found between the 
      concentrations of certain POPs and testosterone. Contaminant-related changes in 
      the relative concentrations of testosterone and 17beta-estradiol were also 
      observed. In addition, yolk steroid concentrations were associated with 
      contaminant profiles describing the proportions of different POPs present in the 
      yolk. Eggs from nests in which two sibling eggs hatched or failed to hatch 
      differed in POP profiles and in the relative concentrations of testosterone and 
      17beta-estradiol. Although the results of this correlative study need to be 
      interpreted with caution, they suggest that contaminant-related changes in yolk 
      steroids may occur, possibly affecting offspring performance over and above toxic 
      effects brought about by POPs in eggs.
FAU - Verboven, Nanette
AU  - Verboven N
AD  - Division of Cell Sciences, Institute of Comparative Medicine, University of 
      Glasgow Veterinary School, 464 Bearsden Road, Glasgow G61 1QH, Scotland, UK.
FAU - Verreault, Jonathan
AU  - Verreault J
FAU - Letcher, Robert J
AU  - Letcher RJ
FAU - Gabrielsen, Geir W
AU  - Gabrielsen GW
FAU - Evans, Neil P
AU  - Evans NP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080502
PL  - United States
TA  - Comp Biochem Physiol C Toxicol Pharmacol
JT  - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
JID - 100959500
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Halogenated)
RN  - 3XMK78S47O (Testosterone)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Arctic Regions
MH  - Charadriiformes/*metabolism
MH  - Clutch Size
MH  - Egg Yolk/*drug effects/metabolism
MH  - Environmental Pollutants/metabolism/*toxicity
MH  - Estradiol/*metabolism
MH  - Female
MH  - Food Chain
MH  - Hydrocarbons, Halogenated/metabolism/*toxicity
MH  - Norway
MH  - Oviparity
MH  - *Reproduction
MH  - Seasons
MH  - Testosterone/*metabolism
MH  - Zygote/*drug effects/metabolism
EDAT- 2008/06/14 09:00
MHDA- 2008/09/26 09:00
CRDT- 2008/06/14 09:00
PHST- 2008/03/03 00:00 [received]
PHST- 2008/04/28 00:00 [revised]
PHST- 2008/04/28 00:00 [accepted]
PHST- 2008/06/14 09:00 [pubmed]
PHST- 2008/09/26 09:00 [medline]
PHST- 2008/06/14 09:00 [entrez]
AID - S1532-0456(08)00074-4 [pii]
AID - 10.1016/j.cbpc.2008.04.010 [doi]
PST - ppublish
SO  - Comp Biochem Physiol C Toxicol Pharmacol. 2008 Aug;148(2):143-51. doi: 
      10.1016/j.cbpc.2008.04.010. Epub 2008 May 2.