PMID- 18550492
OWN - NLM
STAT- MEDLINE
DCOM- 20090319
LR  - 20221207
IS  - 0253-9772 (Print)
IS  - 0253-9772 (Linking)
VI  - 30
IP  - 6
DP  - 2008 Jun
TI  - [Association studies of the APM1 SNP T45G with type 2 diabetes in Han population 
      of Hubei Province].
PG  - 711-5
AB  - To investigate the association between the APM1 SNP rs 13061862 and type 2 
      diabetes mellitus (T2DM), a total of 603 Han subjects from Hubei Province were 
      genotyped for the APM1 SNP T45G. Both family-based case- control and unrelated 
      case-control designs were used. The frequencies of the G allele and GG genotype 
      for T2DM patients were significantly higher than those for controls (G: 42.0% vs. 
      21.7%, P<0.001; GG: 13.6% vs. 4.5%, P= 0.032) in all subjects. The GG genotype 
      was associated with higher risk of T2DM in family-based case-control groups (GG: 
      17.8% vs. 5.6%, P = 0.011), while the G allele and GG genotype for T2DM patients 
      were significantly higher than those for controls in the unrelated case-control 
      groups (GG: 12.2% vs. 3.9%, P = 0.025). Logistic regression analysis suggested 
      that GG genotype was the genetic risk factors for T2DM (OR = 3.58, 95% CI = 
      1.70-7.54). In conclusion, the APM1 SNP T45G is associated with T2DM risk, and 
      the GG genotype may be a genetic risk factor of T2DM in Han population of Hubei 
      Province.
FAU - Wang, Yan
AU  - Wang Y
AD  - College of Life Sciences, Central China Normal University, Wuhan 430079, China. 
      wangyan126@mails.ccnu.edu.cn
FAU - Zhang, Jun
AU  - Zhang J
FAU - Huang, Qing-Yang
AU  - Huang QY
LA  - chi
PT  - Journal Article
PL  - China
TA  - Yi Chuan
JT  - Yi chuan = Hereditas
JID - 9436478
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
SB  - IM
MH  - Adiponectin/genetics
MH  - Aged
MH  - Asian People/genetics
MH  - China
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
EDAT- 2008/06/14 09:00
MHDA- 2009/03/20 09:00
CRDT- 2008/06/14 09:00
PHST- 2008/06/14 09:00 [pubmed]
PHST- 2009/03/20 09:00 [medline]
PHST- 2008/06/14 09:00 [entrez]
AID - 0253-9772(2008)06-711-05 [pii]
AID - 10.3724/sp.j.1005.2008.00711 [doi]
PST - ppublish
SO  - Yi Chuan. 2008 Jun;30(6):711-5. doi: 10.3724/sp.j.1005.2008.00711.