PMID- 18550922 OWN - NLM STAT- MEDLINE DCOM- 20081003 LR - 20191110 IS - 1527-5299 (Print) IS - 1527-5299 (Linking) VI - 14 IP - 3 DP - 2008 May-Jun TI - Invasive and noninvasive correlations of B-type natriuretic peptide in patients with heart failure due to Chagas cardiomyopathy. PG - 121-6 AB - Heart failure due to Chagas cardiomyopathy (HFCC) differs from failure with other etiologies because of the occurrence of intense inflammatory infiltrate and right ventricle compromise. This article investigates correlations of B-type natriuretic peptide (BNP) levels with parameters of severity in HFCC. Twenty-eight patients and 8 normal controls underwent heart catheterization and clinical and laboratory analyses. BNP levels were higher in patients with HFCC (P<.0001) and correlated with New York Heart Association (NYHA) class; right atrial pressure; wedge pressure; cardiac output; levels of serum sodium, hemoglobin, urea, and tumor necrosis factor-alpha; and ejection fraction. Interferon-gamma and transforming growth factor-beta did not correlate with BNP level. The authors conclude that BNP levels are elevated in patients experiencing HFCC, irrespective of NYHA class, and that the occurrence of HFCC correlates with severity of disease. FAU - Vilas-Boas, Fabio AU - Vilas-Boas F AD - Heart Failure Clinics and Academic Research Department of Santa Izabel Hospital, Salvador, BA, Brazil. fabiovboas@cardiol.br FAU - Feitosa, Gilson Soares AU - Feitosa GS FAU - Soares, Milena B P AU - Soares MB FAU - Pinho-Filho, Joel Alves AU - Pinho-Filho JA FAU - Nascimento, Thais AU - Nascimento T FAU - Barojas, Marcos M AU - Barojas MM FAU - Andrade, Marcus V S AU - Andrade MV FAU - Ribeiro-Dos-Santos, Ricardo AU - Ribeiro-Dos-Santos R FAU - Bocchi, Edimar AU - Bocchi E LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. PL - United States TA - Congest Heart Fail JT - Congestive heart failure (Greenwich, Conn.) JID - 9714174 RN - 114471-18-0 (Natriuretic Peptide, Brain) SB - IM MH - Cardiac Catheterization MH - Case-Control Studies MH - Chagas Cardiomyopathy/blood/*complications/physiopathology MH - Diastole MH - Exercise Tolerance MH - Female MH - Heart Failure/blood/*etiology/physiopathology MH - Hemodynamics MH - Humans MH - Male MH - Middle Aged MH - Natriuretic Peptide, Brain/*blood MH - Prospective Studies MH - Risk Assessment MH - Risk Factors MH - Surveys and Questionnaires MH - Systole EDAT- 2008/06/14 09:00 MHDA- 2008/10/04 09:00 CRDT- 2008/06/14 09:00 PHST- 2008/06/14 09:00 [pubmed] PHST- 2008/10/04 09:00 [medline] PHST- 2008/06/14 09:00 [entrez] AID - 10.1111/j.1751-7133.2008.08166.x [doi] PST - ppublish SO - Congest Heart Fail. 2008 May-Jun;14(3):121-6. doi: 10.1111/j.1751-7133.2008.08166.x.