PMID- 18551309
OWN - NLM
STAT- MEDLINE
DCOM- 20081124
LR  - 20211020
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 453
IP  - 2
DP  - 2008 Aug
TI  - Mixed-type liposarcoma: clinicopathological, immunohistochemical, and molecular 
      analysis of a case arising in deep soft tissues of the lower extremity.
PG  - 197-201
LID - 10.1007/s00428-008-0624-7 [doi]
AB  - A rare case of mixed-type liposarcoma arising in deep soft tissue of the right 
      thigh of a 45-year-old female patient is reported. The neoplasm was completely 
      excised and was composed of an irregular admixture of areas of atypical 
      lipomatous tumor/well-differentiated liposarcoma of the lipoma-like subtype with 
      areas of myxoid/round cell liposarcoma. An amplification of the MDM2 and CDK4 
      genes respectively in the atypical lipomatous tumor/well-differentiated 
      liposarcoma areas was detected by fluorescence in situ hybridization (FISH) 
      analysis, and translocations of the CHOP and FUS genes were detected by FISH 
      analysis in the myxoid/round cell liposarcoma areas.
FAU - Mentzel, Thomas
AU  - Mentzel T
AD  - Dermatopathologische Gemeinschaftspraxis, Siemensstrasse 6/1, 88048, 
      Friedrichshafen, Germany. mentzel@dermpath.de
FAU - Palmedo, Gabriele
AU  - Palmedo G
FAU - Hantschke, Markus
AU  - Hantschke M
FAU - Woziwodzki, Jorg
AU  - Woziwodzki J
FAU - Beck, Christian
AU  - Beck C
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20080613
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (DDIT3 protein, human)
RN  - 0 (RNA-Binding Protein FUS)
RN  - 147336-12-7 (Transcription Factor CHOP)
RN  - EC 2.3.2.27 (MDM2 protein, human)
RN  - EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2)
RN  - EC 2.7.11.22 (CDK4 protein, human)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinase 4)
SB  - IM
MH  - Cyclin-Dependent Kinase 4/metabolism
MH  - Female
MH  - Gene Expression Profiling
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Liposarcoma/chemistry/*pathology
MH  - Liposarcoma, Myxoid/chemistry/*pathology
MH  - Middle Aged
MH  - Proto-Oncogene Proteins c-mdm2/metabolism
MH  - RNA-Binding Protein FUS/genetics
MH  - Thigh
MH  - Transcription Factor CHOP/genetics
MH  - Translocation, Genetic
EDAT- 2008/06/14 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/06/14 09:00
PHST- 2008/04/07 00:00 [received]
PHST- 2008/05/05 00:00 [accepted]
PHST- 2008/05/05 00:00 [revised]
PHST- 2008/06/14 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/06/14 09:00 [entrez]
AID - 10.1007/s00428-008-0624-7 [doi]
PST - ppublish
SO  - Virchows Arch. 2008 Aug;453(2):197-201. doi: 10.1007/s00428-008-0624-7. Epub 2008 
      Jun 13.