PMID- 18551998
OWN - NLM
STAT- MEDLINE
DCOM- 20080829
LR  - 20151029
IS  - 0030-6657 (Print)
IS  - 0030-6657 (Linking)
VI  - 61
IP  - 5
DP  - 2007
TI  - [Prognostic value of CDC25 phosphatases expression in laryngeal cancer].
PG  - 668-74
LID - 10.1016/S0030-6657(07)70504-8 [doi]
AB  - CDC25 phosphatases, significant positive regulators of the cell cycle play a 
      pivotal role in controlling cell proliferation during development and 
      tumorigenesis. The prevalence and clinical implications of CDC25 immunoreactivity 
      in laryngeal squamous cell cancer (LSCC) patients however, have not been 
      elucidated. AIM: The object of the study was to assess the relationship between 
      the expression levels of CDC25A, CDC25B and clinicopathological parameters and 
      overall survival time of patients with LSCC. MATERIAL AND METHODS: Tissue blocks 
      from 46 patients treated surgically at our institution between 1992 and 2000 were 
      available for this study. Immunohistochemistry using polyclonal antibodies 
      against CDC25A and CDC25B was used to examine proteins expression. Ki-67 antigen 
      expression was examined as a cell proliferation marker. Control group consisted 
      of 21 samples of unchanged mucosa. RESULTS: CDC25A and CDC25B expression was 
      observed in 96% (44/46) and 56.5% (26/46) of tumors; the mean labeling index was 
      73.9% and 36.5% respectively. CDC25 phosphatases expression was higher in LSCC 
      compare to the control group (p<0.001). There was not any significant correlation 
      between the levels of CDC25 phosphatases and investigated variables. In 
      univariate analysis, all classical clinicopathological parameters but none of the 
      proteins were related to the overall survival time. CONCLUSIONS: The expression 
      of CDC25A, CDC25B and the proliferation marker Ki-67 are not associated with 
      prognosis in LSCC.
FAU - Fraczek, Marcin
AU  - Fraczek M
AD  - Klinika Otolaryngologii Akademii Medycznej we Wroclawiu.
FAU - Wozniak, Zdzislaw
AU  - Wozniak Z
FAU - Ramsey, David
AU  - Ramsey D
FAU - Zatonski, Tomasz
AU  - Zatonski T
FAU - Nadolska, Beata
AU  - Nadolska B
FAU - Krecicki, Tomasz
AU  - Krecicki T
LA  - pol
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Znaczenie prognostyczne ekspresji kwasnych fosfataz CDC25 w raku krtani.
PL  - Poland
TA  - Otolaryngol Pol
JT  - Otolaryngologia polska = The Polish otolaryngology
JID - 0404453
RN  - 0 (Ki-67 Antigen)
RN  - EC 3.1.3.48 (cdc25 Phosphatases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*enzymology
MH  - Female
MH  - Gene Expression
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - Ki-67 Antigen/*biosynthesis
MH  - Laryngeal Neoplasms/*enzymology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - cdc25 Phosphatases/*biosynthesis
EDAT- 2008/06/17 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/06/17 09:00
PHST- 2008/06/17 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/06/17 09:00 [entrez]
AID - S0030-6657(07)70504-8 [pii]
AID - 10.1016/S0030-6657(07)70504-8 [doi]
PST - ppublish
SO  - Otolaryngol Pol. 2007;61(5):668-74. doi: 10.1016/S0030-6657(07)70504-8.