PMID- 18552411
OWN - NLM
STAT- MEDLINE
DCOM- 20081107
LR  - 20220318
IS  - 1735-1502 (Print)
IS  - 1735-1502 (Linking)
VI  - 7
IP  - 2
DP  - 2008 Jun
TI  - Association of HLA-DQB1 allelic sequence variation with susceptibility to 
      systemic lupus erythematosus.
PG  - 91-5
AB  - Systemic lupus erythematosus (SLE) is an autoimmune disease in which 
      polymorphisms within the human leukocyte antigen (HLA) region have been 
      associated to its etiology. We conducted this study to compare the HLA-DQB1 
      allelic sequence variation among SLE patients and controls in the northeast of 
      Iran. Genomic DNA of 40 SLE patients and 83 healthy controls were amplified by 
      Polymerase Chain Reaction with Sequence-Specific Primers technique (PCR-SSP). 
      Seven serological subclasses of the HLA DQB1 were detected. Allele distribution 
      comparison showed in the SLE group a significant increase of HLA DQ6 
      (*0601-*0609) (p=0.006); whereas alleles HLA DQ7 (*0301-*0304) were significantly 
      decreased (p=0.005). Combination of DQ5 (*0501-*0504)-DQ6 (*0601-*0609) was 
      increased in patients. These results suggest that DQ6 is the dominant HLA DQB1 
      allele probably associated with genetic susceptibility to SLE in the northeast of 
      Iran. The association supports the importance of ethnic background and indicates 
      the importance of various genes that has been observed in different SLE 
      populations.
FAU - Rezaieyazdi, Zahra
AU  - Rezaieyazdi Z
AD  - Department of Rheumatology, Ghaem Hospital, Mashhad University of Medical 
      Sciences, Mashhad, Iran. rezaieyazdi-z@mums.ac.ir
FAU - Tavakkol-Afshari, Jalil
AU  - Tavakkol-Afshari J
FAU - Esmaili, Ehsan
AU  - Esmaili E
FAU - Orouji, Elyas
AU  - Orouji E
FAU - Pezeshkpour, Fakhrozaman
AU  - Pezeshkpour F
FAU - Khodadoost, Mohammad
AU  - Khodadoost M
FAU - Mazhani, Maryam
AU  - Mazhani M
FAU - Sandooghi, Mahnaz
AU  - Sandooghi M
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ6 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - Humans
MH  - Iran
MH  - Lupus Erythematosus, Systemic/*genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
EDAT- 2008/06/17 09:00
MHDA- 2008/11/08 09:00
CRDT- 2008/06/17 09:00
PHST- 2008/06/17 09:00 [pubmed]
PHST- 2008/11/08 09:00 [medline]
PHST- 2008/06/17 09:00 [entrez]
AID - 07029195 [pii]
PST - ppublish
SO  - Iran J Allergy Asthma Immunol. 2008 Jun;7(2):91-5.