PMID- 18553142
OWN - NLM
STAT- MEDLINE
DCOM- 20091002
LR  - 20121115
IS  - 1573-6822 (Electronic)
IS  - 0742-2091 (Linking)
VI  - 25
IP  - 4
DP  - 2009 Aug
TI  - Effect of sulfite treatment on total antioxidant capacity, total oxidant status, 
      lipid hydroperoxide, and total free sulfydryl groups contents in normal and 
      sulfite oxidase-deficient rat plasma.
PG  - 355-62
LID - 10.1007/s10565-008-9089-3 [doi]
AB  - Sulfites, which are commonly used as preservatives, are continuously formed in 
      the body during the metabolism of sulfur-containing amino acids. Sulfite oxidase 
      (SOX) is an essential enzyme in the pathway of the oxidative degradation of 
      sulfite to sulfate protecting cells from sulfite toxicity. This article 
      investigated the effect of sulfite on total antioxidant capacity (TAC), total 
      oxidant status, lipid hydroperoxide (LOOH), and total free sulfydryl groups (-SH) 
      levels in normal and SOX-deficient male albino rat plasma. For this purpose, rats 
      were divided into four groups: control, sulfite-treated, SOX-deficient, and 
      sulfite-treated SOX-deficient groups. SOX deficiency was established by feeding 
      rats a low molybdenum diet and adding to their drinking water 200 ppm tungsten. 
      Sulfite (70 mg/kg) was administered to the animals via their drinking water. SOX 
      deficiency together with sulfite treatment caused a significant increase in the 
      plasma LOOH and total oxidant status levels. -SH content of rat plasma 
      significantly decreased by both sulfite treatment and SOX deficiency compared to 
      the control. There was also a significant decrease in plasma TAC level by sulfite 
      treatment. In conclusion, sulfite treatment affects the antioxidant/oxidant 
      balance of the plasma cells of the rats toward oxidants in SOX-deficient groups.
FAU - Herken, Emine Nur
AU  - Herken EN
AD  - Faculty of Engineering, Department of Food Engineering, Pamukkale University, 
      Kinikli 20020, Denizli, Turkey. nurherken@pau.edu.tr
FAU - Kocamaz, Erdogan
AU  - Kocamaz E
FAU - Erel, Ozcan
AU  - Erel O
FAU - Celik, Hakim
AU  - Celik H
FAU - Kucukatay, Vural
AU  - Kucukatay V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080614
PL  - Switzerland
TA  - Cell Biol Toxicol
JT  - Cell biology and toxicology
JID - 8506639
RN  - 0 (Food Preservatives)
RN  - 0 (Free Radicals)
RN  - 0 (Lipid Peroxides)
RN  - 0 (Sulfhydryl Compounds)
RN  - 0 (Sulfites)
RN  - 4VON5FNS3C (sodium metabisulfite)
RN  - EC 1.8.3.1 (Sulfite Oxidase)
SB  - IM
MH  - Animals
MH  - Food Preservatives/*pharmacology
MH  - Free Radicals/blood
MH  - Lipid Peroxides/*blood
MH  - Male
MH  - Oxidation-Reduction
MH  - Rats
MH  - Sulfhydryl Compounds/*blood
MH  - Sulfite Oxidase/*blood/deficiency
MH  - Sulfites/*pharmacology
EDAT- 2008/06/17 09:00
MHDA- 2009/10/03 06:00
CRDT- 2008/06/17 09:00
PHST- 2008/02/01 00:00 [received]
PHST- 2008/05/18 00:00 [accepted]
PHST- 2008/06/17 09:00 [pubmed]
PHST- 2009/10/03 06:00 [medline]
PHST- 2008/06/17 09:00 [entrez]
AID - 10.1007/s10565-008-9089-3 [doi]
PST - ppublish
SO  - Cell Biol Toxicol. 2009 Aug;25(4):355-62. doi: 10.1007/s10565-008-9089-3. Epub 
      2008 Jun 14.