PMID- 18554520
OWN - NLM
STAT- MEDLINE
DCOM- 20081003
LR  - 20220311
IS  - 0891-5849 (Print)
IS  - 0891-5849 (Linking)
VI  - 45
IP  - 5
DP  - 2008 Sep 1
TI  - Microglia and myeloperoxidase: a deadly partnership in neurodegenerative disease.
PG  - 726-31
LID - 10.1016/j.freeradbiomed.2008.05.021 [doi]
AB  - The role of inflammation in Alzheimer's disease, Parkinson's disease, and 
      multiple sclerosis has recently come under increased scrutiny. Associated with 
      these inflammatory responses are tumor necrosis factor-alpha (TNF-alpha) and 
      reactive oxygen species (ROS), both believed to be derived from brain microglia. 
      In addition to the above, the presence of myeloperoxidase (MPO) in these diseased 
      brains has been reported by a number of investigators. However, the possible role 
      of MPO and enzymatically inactive MPO (iMPO) as the "choreographers" of the 
      destruction done by TNF-alpha and ROS is not generally recognized. Previously, 
      our laboratory has reported that MPO/iMPO enhance macrophage generation of ROS 
      and expression of proinflammatory cytokine genes as well as gene products. Recent 
      studies in our laboratory indicate that the same response occurs with microglia. 
      A paradigm is presented for the perpetuation of inflammation associated with 
      neurodegenerative diseases. This model describes the unrecognized consequences of 
      the stimulation of microglia by MPO or iMPO. Both MPO and iMPO and/or its 
      receptor may represent new therapeutic targets for the treatment of these 
      diseases.
FAU - Lefkowitz, Doris L
AU  - Lefkowitz DL
AD  - School of Biological Sciences, Section of Molecular Genetics and Microbiology, 
      University of Texas at Austin, 1 University Station A5000, Austin, TX 78712-0162, 
      USA. sslefkowitz@yahoo.com
FAU - Lefkowitz, Stanley S
AU  - Lefkowitz SS
LA  - eng
PT  - Journal Article
DEP - 20080603
PL  - United States
TA  - Free Radic Biol Med
JT  - Free radical biology & medicine
JID - 8709159
RN  - 0 (Lectins, C-Type)
RN  - 0 (Mannose Receptor)
RN  - 0 (Mannose-Binding Lectins)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Receptors, Cell Surface)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Animals
MH  - Brain/metabolism
MH  - Humans
MH  - Lectins, C-Type/metabolism
MH  - Mannose Receptor
MH  - Mannose-Binding Lectins/metabolism
MH  - Microglia/*enzymology
MH  - Models, Neurological
MH  - Neurodegenerative Diseases/*enzymology
MH  - Peroxidase/*metabolism
MH  - Reactive Oxygen Species/metabolism
MH  - Receptors, Cell Surface/metabolism
EDAT- 2008/06/17 09:00
MHDA- 2008/10/04 09:00
CRDT- 2008/06/17 09:00
PHST- 2008/02/26 00:00 [received]
PHST- 2008/05/03 00:00 [revised]
PHST- 2008/05/21 00:00 [accepted]
PHST- 2008/06/17 09:00 [pubmed]
PHST- 2008/10/04 09:00 [medline]
PHST- 2008/06/17 09:00 [entrez]
AID - S0891-5849(08)00329-8 [pii]
AID - 10.1016/j.freeradbiomed.2008.05.021 [doi]
PST - ppublish
SO  - Free Radic Biol Med. 2008 Sep 1;45(5):726-31. doi: 
      10.1016/j.freeradbiomed.2008.05.021. Epub 2008 Jun 3.