PMID- 18555540
OWN - NLM
STAT- MEDLINE
DCOM- 20081105
LR  - 20080714
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 197
IP  - 2
DP  - 2008 Jul 15
TI  - Interferon-beta induces brain-derived neurotrophic factor in peripheral blood 
      mononuclear cells of multiple sclerosis patients.
PG  - 147-51
LID - 10.1016/j.jneuroim.2008.04.033 [doi]
AB  - Interferon-beta (IFN-beta) achieves its beneficial effect on multiple sclerosis 
      (MS) via anti-inflammatory properties. In this study, we assessed the expression 
      of the brain-derived neurotrophic factor (BDNF) in peripheral blood mononuclear 
      cells (PBMC) from relapsing-remitting multiple sclerosis (RRMS) patients treated 
      or not with IFN-beta. Intracellular BDNF was measured by Western blot and ELISA 
      and compared with serum BDNF. We found higher levels of BDNF in PBMC of 
      IFN-beta-treated versus non-treated patients, whereas serum levels of BDNF were 
      similar. We hypothesize that the increased intracellular BDNF secondary to 
      IFN-beta is not released in the periphery. This release is probably not tissue 
      specific but in MS patients, BDNF could be specifically delivered by PBMC at the 
      site of re-activation, i.e. within the central nervous system.
FAU - Lalive, P H
AU  - Lalive PH
AD  - Department of Neurosciences, Neuroimmunology Laboratory, University Hospital of 
      Geneva, Geneva, Switzerland. patrice.lalive@hcuge.ch
FAU - Kantengwa, S
AU  - Kantengwa S
FAU - Benkhoucha, M
AU  - Benkhoucha M
FAU - Juillard, C
AU  - Juillard C
FAU - Chofflon, M
AU  - Chofflon M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080613
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Immunologic Factors)
RN  - 77238-31-4 (Interferon-beta)
SB  - IM
MH  - Adult
MH  - Blotting, Western/methods
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Case-Control Studies
MH  - Dose-Response Relationship, Drug
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Humans
MH  - Immunologic Factors/*pharmacology
MH  - Interferon-beta/*pharmacology
MH  - Leukocytes, Mononuclear/*drug effects
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*pathology
EDAT- 2008/06/17 09:00
MHDA- 2008/11/06 09:00
CRDT- 2008/06/17 09:00
PHST- 2008/01/30 00:00 [received]
PHST- 2008/04/28 00:00 [revised]
PHST- 2008/04/29 00:00 [accepted]
PHST- 2008/06/17 09:00 [pubmed]
PHST- 2008/11/06 09:00 [medline]
PHST- 2008/06/17 09:00 [entrez]
AID - S0165-5728(08)00130-6 [pii]
AID - 10.1016/j.jneuroim.2008.04.033 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2008 Jul 15;197(2):147-51. doi: 10.1016/j.jneuroim.2008.04.033. 
      Epub 2008 Jun 13.