PMID- 18555776
OWN - NLM
STAT- MEDLINE
DCOM- 20080703
LR  - 20220318
IS  - 1097-4172 (Electronic)
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 133
IP  - 6
DP  - 2008 Jun 13
TI  - Systemic endocrine instigation of indolent tumor growth requires osteopontin.
PG  - 994-1005
LID - 10.1016/j.cell.2008.04.045 [doi]
AB  - The effects of primary tumors on the host systemic environment and resulting 
      contributions of the host to tumor growth are poorly understood. Here, we find 
      that human breast carcinomas instigate the growth of otherwise-indolent tumor 
      cells, micrometastases, and human tumor surgical specimens located at distant 
      anatomical sites. This systemic instigation is accompanied by incorporation of 
      bone-marrow cells (BMCs) into the stroma of the distant, once-indolent tumors. We 
      find that BMCs of hosts bearing instigating tumors are functionally activated 
      prior to their mobilization; hence, when coinjected with indolent cells, these 
      activated BMCs mimic the systemic effects imparted by instigating tumors. 
      Secretion of osteopontin by instigating tumors is necessary for BMC activation 
      and the subsequent outgrowth of the distant otherwise-indolent tumors. These 
      results reveal that outgrowth of indolent tumors can be governed on a systemic 
      level by endocrine factors released by certain instigating tumors, and hold 
      important experimental and therapeutic implications.
FAU - McAllister, Sandra S
AU  - McAllister SS
AD  - Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 
      02142, USA.
FAU - Gifford, Ann M
AU  - Gifford AM
FAU - Greiner, Ashley L
AU  - Greiner AL
FAU - Kelleher, Stephen P
AU  - Kelleher SP
FAU - Saelzler, Matthew P
AU  - Saelzler MP
FAU - Ince, Tan A
AU  - Ince TA
FAU - Reinhardt, Ferenc
AU  - Reinhardt F
FAU - Harris, Lyndsay N
AU  - Harris LN
FAU - Hylander, Bonnie L
AU  - Hylander BL
FAU - Repasky, Elizabeth A
AU  - Repasky EA
FAU - Weinberg, Robert A
AU  - Weinberg RA
LA  - eng
GR  - K08 CA092013/CA/NCI NIH HHS/United States
GR  - P01 CA080111/CA/NCI NIH HHS/United States
GR  - P0-CA080111/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 106441-73-0 (Osteopontin)
SB  - IM
MH  - Adenocarcinoma/*metabolism
MH  - Animals
MH  - Bone Marrow Cells/*cytology/metabolism
MH  - Breast Neoplasms/*metabolism
MH  - Cell Division
MH  - Cell Line, Tumor
MH  - Cell Movement
MH  - Colonic Neoplasms/metabolism
MH  - Humans
MH  - Mice
MH  - Mice, Nude
MH  - *Neoplasm Metastasis
MH  - Neoplasm Transplantation
MH  - Osteopontin/*metabolism
MH  - Transplantation, Heterologous
PMC - PMC4121664
MID - NIHMS569129
EDAT- 2008/06/17 09:00
MHDA- 2008/07/04 09:00
PMCR- 2014/08/05
CRDT- 2008/06/17 09:00
PHST- 2007/06/20 00:00 [received]
PHST- 2007/12/10 00:00 [revised]
PHST- 2008/04/17 00:00 [accepted]
PHST- 2008/06/17 09:00 [pubmed]
PHST- 2008/07/04 09:00 [medline]
PHST- 2008/06/17 09:00 [entrez]
PHST- 2014/08/05 00:00 [pmc-release]
AID - S0092-8674(08)00621-1 [pii]
AID - 10.1016/j.cell.2008.04.045 [doi]
PST - ppublish
SO  - Cell. 2008 Jun 13;133(6):994-1005. doi: 10.1016/j.cell.2008.04.045.