PMID- 18556006
OWN - NLM
STAT- MEDLINE
DCOM- 20080924
LR  - 20191210
IS  - 0021-9673 (Print)
IS  - 0021-9673 (Linking)
VI  - 1201
IP  - 1
DP  - 2008 Aug 1
TI  - Determination of multiresidue quinolones regulated by the European Union in pig 
      liver samples. High-resolution time-of-flight mass spectrometry versus tandem 
      mass spectrometry detection.
PG  - 1-14
LID - 10.1016/j.chroma.2008.05.090 [doi]
AB  - The use of liquid chromatography coupled to orthogonal acceleration 
      time-of-flight mass spectrometry (LC-ToF-MS) provides an attractive alternative 
      to liquid chromatography coupled to quadrupole (LC-MS) or triple quadrupole mass 
      spectrometry (LC-MS/MS) in multiresidue analysis. ToF-MS provides accurate mass 
      information and a significantly higher mass resolution than quadrupole analyzers. 
      In this work, the influential parameters in time-of-flight detection using an 
      electrospray ionization (ESI) source were studied using a central composite 
      design to obtain the main effects and their two-factor interactions. The method 
      developed uses LC-ESI-ToF-MS to determine and characterize quinolones regulated 
      by the EU in pig liver samples below the maximum residue limits (MRLs). 
      Linearity, decision limit, detection capability, detection and quantification 
      limits, precision and recoveries were determined and adequate results were 
      obtained, with quantification limits between 1.5 and 6 microg kg(-1) and 
      recoveries higher than 60% for all quinolones. Limits of detection are lower than 
      2 microg kg(-1). Results obtained using LC-ESI-ToF-MS were compared with those 
      obtained using LC coupled to a quadrupole and to triple quadrupole mass 
      spectrometer. The work described in this paper illustrates the suitability and 
      excellent confirmatory potential of LC-ToF-MS for multiresidue analysis in food 
      samples.
FAU - Hermo, M P
AU  - Hermo MP
AD  - Department of Analytical Chemistry, University of Barcelona, Avda. Diagonal 647, 
      E-08028 Barcelona, Spain.
FAU - Barron, D
AU  - Barron D
FAU - Barbosa, J
AU  - Barbosa J
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080604
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Liver Extracts)
RN  - 0 (Quinolones)
SB  - IM
MH  - Animals
MH  - Chromatography, Liquid/methods
MH  - Food Analysis
MH  - Liver/*chemistry
MH  - Liver Extracts/chemistry
MH  - Mass Spectrometry/*methods
MH  - Quinolones/*chemistry/isolation & purification
MH  - Sensitivity and Specificity
MH  - Swine
EDAT- 2008/06/17 09:00
MHDA- 2008/09/25 09:00
CRDT- 2008/06/17 09:00
PHST- 2007/11/13 00:00 [received]
PHST- 2008/05/15 00:00 [revised]
PHST- 2008/05/28 00:00 [accepted]
PHST- 2008/06/17 09:00 [pubmed]
PHST- 2008/09/25 09:00 [medline]
PHST- 2008/06/17 09:00 [entrez]
AID - S0021-9673(08)00984-9 [pii]
AID - 10.1016/j.chroma.2008.05.090 [doi]
PST - ppublish
SO  - J Chromatogr A. 2008 Aug 1;1201(1):1-14. doi: 10.1016/j.chroma.2008.05.090. Epub 
      2008 Jun 4.