PMID- 18556104
OWN - NLM
STAT- MEDLINE
DCOM- 20081022
LR  - 20131121
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 32
IP  - 6
DP  - 2008 Aug 1
TI  - The inhibitory effect of trimethylamine on the anticonvulsant activities of 
      quinine in the pentylenetetrazole model in rats.
PG  - 1496-500
LID - 10.1016/j.pnpbp.2008.05.007 [doi]
AB  - Quinine specifically blocks connexin 36 (Cx36), one of the proteins that form gap 
      junction channels. Quinine suppressed ictal epileptiform activity in in vitro and 
      in vivo studies without decreasing neuronal excitability. In this study, we 
      considered the possible mechanism of anticonvulsant effects of quinine (1, 250, 
      500, 1000 and 2000 microM, i.c.v.) in the pentylenetetrazole (PTZ) model of 
      seizure. Thus, we used trimethylamine (TMA) (0.05 microM, 5 microM, 50 microM), a 
      gap junction channel opener, to examine whether it could reverse the effects of 
      quinine in rats. Intracerebroventricular (i.c.v.) injection of quinine affected 
      generalized tonic-clonic seizure (GTCS) induced by PTZ by increments in seizure 
      onset and reducing seizure duration. Additionally, pretreatment with different 
      doses of TMA (i.c.v.) attenuated the anticonvulsant effects of quinine on the 
      latency and duration of GTCS. It can be concluded that quinine possesses 
      anticonvulsant effects via modulation of gap junction channels, which could 
      contribute to the control of GTCS.
FAU - Nassiri-Asl, Marjan
AU  - Nassiri-Asl M
AD  - Department of Pharmacology, School of Medicine, Qazvin University of Medical 
      Sciences, Qazvin, Iran. marjannassiriaslm@gmail.com
FAU - Zamansoltani, Farzaneh
AU  - Zamansoltani F
FAU - Zangivand, Amir-Abdollah
AU  - Zangivand AA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080516
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Anticonvulsants)
RN  - 0 (Convulsants)
RN  - 0 (Methylamines)
RN  - A7V27PHC7A (Quinine)
RN  - LHH7G8O305 (trimethylamine)
RN  - WM5Z385K7T (Pentylenetetrazole)
SB  - IM
MH  - Animals
MH  - Anticonvulsants/*antagonists & inhibitors
MH  - Convulsants
MH  - Gap Junctions/drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Methylamines/*pharmacology
MH  - Microinjections
MH  - Pentylenetetrazole
MH  - Quinine/*antagonists & inhibitors
MH  - Rats
MH  - Rats, Wistar
MH  - Seizures/chemically induced/*prevention & control
EDAT- 2008/06/17 09:00
MHDA- 2008/10/23 09:00
CRDT- 2008/06/17 09:00
PHST- 2008/03/23 00:00 [received]
PHST- 2008/05/06 00:00 [revised]
PHST- 2008/05/09 00:00 [accepted]
PHST- 2008/06/17 09:00 [pubmed]
PHST- 2008/10/23 09:00 [medline]
PHST- 2008/06/17 09:00 [entrez]
AID - S0278-5846(08)00142-5 [pii]
AID - 10.1016/j.pnpbp.2008.05.007 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2008 Aug 1;32(6):1496-500. doi: 
      10.1016/j.pnpbp.2008.05.007. Epub 2008 May 16.