PMID- 18557598
OWN - NLM
STAT- MEDLINE
DCOM- 20080818
LR  - 20200924
IS  - 0048-7554 (Print)
IS  - 0048-7554 (Linking)
VI  - 23
IP  - 1
DP  - 2008 Jan-Mar
TI  - Environmental contaminants as risk factors for developing diabetes.
PG  - 59-74
AB  - The contribution of exposure to persistent organic pollutants (POPs) to the 
      incidence of diabetes has received little attention until recently. A number of 
      reports have emerged, however, concerning elevated diabetes in persons 
      occupationally exposed to dioxin. United States (US) Air Force personnel in 
      Vietnam who sprayed Agent Orange containing dioxin as a contaminant had elevated 
      rates of diabetes, leading to US government compensation for diabetes in these 
      veterans. Recent studies in populations exposed to polychlorinated biphenyls 
      (PCBs) and chlorinated pesticides found a dose-dependent elevated risk of 
      diabetes. An elevation in risk of diabetes in relation to levels of several POPs 
      has been demonstrated by two different groups using the National Health and 
      Nutrition Examination Survey (NHANES), a random sampling of US citizens. The 
      strong associations seen in quite different studies suggest the possibility that 
      exposure to POPs could cause diabetes. One striking observation is that obese 
      persons that do not have elevated POPs are not at elevated risk of diabetes, 
      suggesting that the POPs rather than the obesity per se is responsible for the 
      association. Although a specific mechanism is not known, most POPs induce a great 
      number and variety of genes, including several that alter insulin action. Because 
      diabetes is a dangerous disease that is increasing in frequency throughout the 
      world, further study of the possibility that exposure to POPs contributes to the 
      etiology of diabetes is critical.
FAU - Carpenter, David O
AU  - Carpenter DO
AD  - Institute for Health and the Environment, University at Albany, Rensselaer, NY 
      12144, USA. carpent@uamail.albany.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Rev Environ Health
JT  - Reviews on environmental health
JID - 0425754
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Diabetes Mellitus/chemically induced/*etiology
MH  - Environmental Pollutants/*toxicity
MH  - Humans
MH  - Risk Factors
RF  - 91
EDAT- 2008/06/19 09:00
MHDA- 2008/08/19 09:00
CRDT- 2008/06/19 09:00
PHST- 2008/06/19 09:00 [pubmed]
PHST- 2008/08/19 09:00 [medline]
PHST- 2008/06/19 09:00 [entrez]
AID - 10.1515/REVEH.2008.23.1.59 [doi]
PST - ppublish
SO  - Rev Environ Health. 2008 Jan-Mar;23(1):59-74. doi: 10.1515/REVEH.2008.23.1.59.