PMID- 18558290
OWN - NLM
STAT- MEDLINE
DCOM- 20080807
LR  - 20080618
IS  - 1873-4456 (Electronic)
IS  - 0165-4608 (Linking)
VI  - 184
IP  - 1
DP  - 2008 Jul
TI  - Molecular cytogenetic investigations in a novel complex variant of 
      t(8;21)(q22;q22) with ins(15;21)(q15;q22.2q22.3) in a patient with AML-M2 
      subtype.
PG  - 52-6
LID - 10.1016/j.cancergencyto.2008.03.008 [doi]
AB  - Acute myeloid leukemia (AML) is a clinically and molecularly heterogeneous 
      disease characterized by the aberrant proliferation of myeloid stem cells, 
      reduced apoptosis and blockage in cellular differentiation. The present report 
      describes the results of hematological, cytogenetic, and fluorescence in situ 
      hybridization (FISH) analysis in a 25-year-old man diagnosed with AML-M2. 
      Cytogenetic as well as FISH analysis revealed a complex translocation involving 
      four chromosomes, with the karyotype 
      45,-Y,der(X)t(X;8)(p21;q22),der(8)t(8;21)(q22;q22),ins(15;21)(q15;q22.2q22.3),der(21)t(8;21)(q22;q22). 
      The breakpoints at 8q22 and 21q22 suggested a rearrangement of the RUNX1T1 (alias 
      ETO) and RUNX1 (previously AML1) genes, respectively. Using a dual-color FISH 
      test with RUNX1T1 and RUNX1 probes, we demonstrated an RUNX1/RUNX1T1 fusion 
      signal on the derivative chromosome 8, establishing this translocation as a novel 
      complex variant of t(8;21)(q22;q22).
FAU - Kokate, Prajakta
AU  - Kokate P
AD  - Cancer Cytogenetic Division, SRL Ranbaxy Ltd., Plot No. 124, 17th Street, MIDC, 
      Andheri (E), Mumbai 400093, India.
FAU - Ahmad, Firoz
AU  - Ahmad F
FAU - Dalvi, Rupa
AU  - Dalvi R
FAU - Das, Bibhu Ranjan
AU  - Das BR
FAU - Mandava, Swarna
AU  - Mandava S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - *Chromosomes, Human, Pair 21
MH  - *Chromosomes, Human, Pair 8
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - *Translocation, Genetic
EDAT- 2008/06/19 09:00
MHDA- 2008/08/08 09:00
CRDT- 2008/06/19 09:00
PHST- 2007/12/28 00:00 [received]
PHST- 2008/02/29 00:00 [revised]
PHST- 2008/03/13 00:00 [accepted]
PHST- 2008/06/19 09:00 [pubmed]
PHST- 2008/08/08 09:00 [medline]
PHST- 2008/06/19 09:00 [entrez]
AID - S0165-4608(08)00197-0 [pii]
AID - 10.1016/j.cancergencyto.2008.03.008 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2008 Jul;184(1):52-6. doi: 
      10.1016/j.cancergencyto.2008.03.008.