PMID- 18558360
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20110214
IS  - 1568-9972 (Print)
IS  - 1568-9972 (Linking)
VI  - 7
IP  - 6
DP  - 2008 Jun
TI  - Intravenous immunoglobulin - indications and mechanisms in cardiovascular 
      diseases.
PG  - 445-52
LID - 10.1016/j.autrev.2008.04.001 [doi]
AB  - Intravenous immunoglobulin (IVIG) is efficient in various immune mediated 
      conditions. Various cardiovascular diseases are mediated by inflammatory 
      processes and autoimmune mechanisms. Therefore, it seems conceivable to employ 
      IVIG as an immunomodulating therapy in such indications. In this paper we review 
      the possible anti-inflammatory effects of IVIG transfusion, and discuss the 
      possible clinical implications in cardiology. Besides the established use of IVIG 
      in Kawasaki disease, IVIG may be beneficial in some cases of heart failure, 
      dilated cardiomyopathy, myocarditis, pericardial diseases, neonatal lupus, in the 
      prevention of cardiac rejection following transplantation, and in modulating 
      atherosclerosis. IVIG has been proven to be ineffective in rheumatic fever. 
      Although uncommon, complications may arise including myocardial infarction, renal 
      failure and hyperviscosity. IVIG should be administered based on accepted modes 
      of transfusion.
FAU - Nussinovitch, Udi
AU  - Nussinovitch U
AD  - Department of Medicine B, Sackler Faculty of Medicine, Tel-Aviv University, 
      Israel.
FAU - Shoenfeld, Yehuda
AU  - Shoenfeld Y
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20080430
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
EIN - Autoimmun Rev. 2011 Jan;10(3):180. Udi, Nussinovitch [corrected to Nussinovitch, 
      Udi]; Yehuda, Shoenfeld [corrected to Shoenfeld, Yehuda]
MH  - Atherosclerosis/drug therapy
MH  - Cardiomyopathies/drug therapy
MH  - Cardiomyopathy, Dilated/drug therapy
MH  - Cardiovascular Diseases/*drug therapy
MH  - Heart Failure/drug therapy
MH  - Heart Transplantation
MH  - Humans
MH  - Immunoglobulins, Intravenous/pharmacology/*therapeutic use
MH  - Myocarditis/drug therapy
MH  - Rheumatic Fever/drug therapy
RF  - 40
EDAT- 2008/06/19 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/06/19 09:00
PHST- 2008/06/19 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/06/19 09:00 [entrez]
AID - S1568-9972(08)00046-3 [pii]
AID - 10.1016/j.autrev.2008.04.001 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2008 Jun;7(6):445-52. doi: 10.1016/j.autrev.2008.04.001. Epub 2008 
      Apr 30.