PMID- 18558362
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20171116
IS  - 1568-9972 (Print)
IS  - 1568-9972 (Linking)
VI  - 7
IP  - 6
DP  - 2008 Jun
TI  - Naturally occurring anti-band 3 antibodies and red blood cell removal under 
      physiological and pathological conditions.
PG  - 457-62
LID - 10.1016/j.autrev.2008.03.017 [doi]
AB  - Naturally occurring antibodies (NAbs) directed to band 3 protein (major 
      erythrocyte membrane protein) are involved in the clearance of red blood cell 
      (RBC) at the end of their lifespan as well as in the removal of RBC in different 
      hereditary haemolytic disorders and in malaria. In all cited situations RBC 
      undergoes oxidative stress and hemichromes (haemoglobin degradation products) are 
      formed. Hemichromes possess a strong affinity for band 3 cytoplasmic domain and, 
      following their binding, lead to band 3 oxidation and clusterisation. Those band 
      3 clusters show increased affinity for NAbs which activate complement and finally 
      trigger the phagocytosis of altered RBC. During intra-erythrocytic malaria 
      parasite growth, NAbs begin to bind to RBC surface at early parasite development 
      stages increasing their abundance in parallel with parasite development. 
      Interestingly, a number of hereditary haemolytic disorders, known to exert a 
      protective effect on malaria, tend to exacerbate this phenomenon leading to a 
      more precocious and effective opsonization of diseased RBC infected by malaria 
      parasites. The exact definition of band 3 neo-antigens and the mechanism of their 
      surface exposure are still unclear. Also band 3 clusterisation is only 
      superficially understood, new insights about band 3 phosphorylation by Src 
      kinases suggest the presence of a complex regulatory pathway.
FAU - Pantaleo, Antonella
AU  - Pantaleo A
AD  - Department of Genetics, Biology and Biochemistry, University of Torino, Italy.
FAU - Giribaldi, Giuliana
AU  - Giribaldi G
FAU - Mannu, Franca
AU  - Mannu F
FAU - Arese, Paolo
AU  - Arese P
FAU - Turrini, Franco
AU  - Turrini F
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20080421
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
RN  - 0 (Anion Exchange Protein 1, Erythrocyte)
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Anion Exchange Protein 1, Erythrocyte/*immunology
MH  - Autoantibodies/*immunology
MH  - Cellular Senescence
MH  - Erythrocytes/cytology/*immunology/parasitology
MH  - Glucosephosphate Dehydrogenase Deficiency/immunology
MH  - Hemoglobinopathies/*immunology
MH  - Humans
MH  - Malaria/immunology/parasitology
MH  - Thalassemia/immunology
RF  - 40
EDAT- 2008/06/19 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/06/19 09:00
PHST- 2008/01/15 00:00 [received]
PHST- 2008/03/12 00:00 [accepted]
PHST- 2008/06/19 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/06/19 09:00 [entrez]
AID - S1568-9972(08)00032-3 [pii]
AID - 10.1016/j.autrev.2008.03.017 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2008 Jun;7(6):457-62. doi: 10.1016/j.autrev.2008.03.017. Epub 2008 
      Apr 21.