PMID- 18558367
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20080618
IS  - 1568-9972 (Print)
IS  - 1568-9972 (Linking)
VI  - 7
IP  - 6
DP  - 2008 Jun
TI  - Modulation of human dendritic cell maturation and function by natural IgG 
      antibodies.
PG  - 487-90
LID - 10.1016/j.autrev.2008.04.014 [doi]
AB  - Dendritic cells (DCs) are professional antigen-presenting cells, which have a 
      central role in the initiation of primary immune responses and in maintaining 
      immune tolerance. The functions of DCs can be regulated both by environmental 
      signals as well as signals delivered by endogenous molecules. Recently we have 
      examined regulation of human DCs by B cells via natural IgG antibodies. Natural 
      antibodies (NAbs) are defined as antibodies that circulate in normal individuals 
      in the absence of deliberate immunization or microbial aggression. We demonstrate 
      that the differentiation of DCs is severely impaired in primary immunodeficient 
      patients such as X-linked agammaglobulinemia (XLA) and common variable 
      immunodeficiency (CVID) at least in part due to the deficiency of circulating 
      NAbs. Further, we show that NAbs are able to restore normal phenotypes of DCs 
      from patients with XLA and CVID. Our results suggest that B cells promote 
      bystander DC development through NAbs and the interaction between NAbs and DCs 
      may play a role in steady-state migration of DCs.
FAU - Elluru, Sri-Ramulu
AU  - Elluru SR
AD  - Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie - Paris 6, 
      UMR S 872, Paris, F-75006, France.
FAU - Vani, Janakiraman
AU  - Vani J
FAU - Delignat, Sandrine
AU  - Delignat S
FAU - Bloch, Marie-Francoise
AU  - Bloch MF
FAU - Lacroix-Desmazes, Sebastien
AU  - Lacroix-Desmazes S
FAU - Kazatchkine, Michel D
AU  - Kazatchkine MD
FAU - Kaveri, Srini V
AU  - Kaveri SV
FAU - Bayry, Jagadeesh
AU  - Bayry J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080507
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Agammaglobulinemia/genetics/immunology
MH  - B-Lymphocytes/immunology
MH  - Cell Differentiation
MH  - Common Variable Immunodeficiency/immunology
MH  - Dendritic Cells/cytology/*immunology
MH  - Genetic Diseases, X-Linked/immunology
MH  - Humans
MH  - Immunoglobulin G/*physiology
MH  - T-Lymphocytes/immunology
RF  - 38
EDAT- 2008/06/19 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/06/19 09:00
PHST- 2008/06/19 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/06/19 09:00 [entrez]
AID - S1568-9972(08)00058-X [pii]
AID - 10.1016/j.autrev.2008.04.014 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2008 Jun;7(6):487-90. doi: 10.1016/j.autrev.2008.04.014. Epub 2008 
      May 7.