PMID- 18558427
OWN - NLM
STAT- MEDLINE
DCOM- 20081125
LR  - 20211020
IS  - 0091-3057 (Print)
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Linking)
VI  - 90
IP  - 4
DP  - 2008 Oct
TI  - Fetal alcohol spectrum disorder-associated depression: evidence for reductions in 
      the levels of brain-derived neurotrophic factor in a mouse model.
PG  - 614-24
LID - 10.1016/j.pbb.2008.05.004 [doi]
AB  - Prenatal ethanol exposure is associated with an increased incidence of depressive 
      disorders in patient populations. However, the mechanisms that link prenatal 
      ethanol exposure and depression are unknown. Several recent studies have 
      implicated reduced brain-derived neurotrophic factor (BDNF) levels in the 
      hippocampal formation and frontal cortex as important contributors to the 
      etiology of depression. In the present studies, we sought to determine whether 
      prenatal ethanol exposure is associated with behaviors that model depression, as 
      well as with reduced BDNF levels in the hippocampal formation and/or medial 
      frontal cortex, in a mouse model of fetal alcohol spectrum disorder (FASD). 
      Compared to control adult mice, prenatal ethanol-exposed adult mice displayed 
      increased learned helplessness behavior and increased immobility in the Porsolt 
      forced swim test. Prenatal ethanol exposure was associated with decreased BDNF 
      protein levels in the medial frontal cortex, but not the hippocampal formation, 
      while total BDNF mRNA and BDNF transcripts containing exons III, IV or VI were 
      reduced in both the medial frontal cortex and the hippocampal formation of 
      prenatal ethanol-exposed mice. These results identify reduced BDNF levels in the 
      medial frontal cortex and hippocampal formation as potential mediators of 
      depressive disorders associated with FASD.
FAU - Caldwell, Kevin K
AU  - Caldwell KK
AD  - Department of Neurosciences, MSC 08 4740, 1 University of New Mexico, 
      Albuquerque, NM 87131, USA. KCaldwell@salud.unm.edu
FAU - Sheema, S
AU  - Sheema S
FAU - Paz, Rodrigo D
AU  - Paz RD
FAU - Samudio-Ruiz, Sabrina L
AU  - Samudio-Ruiz SL
FAU - Laughlin, Mary H
AU  - Laughlin MH
FAU - Spence, Nathan E
AU  - Spence NE
FAU - Roehlk, Michael J
AU  - Roehlk MJ
FAU - Alcon, Sara N
AU  - Alcon SN
FAU - Allan, Andrea M
AU  - Allan AM
LA  - eng
GR  - T32 AA014127/AA/NIAAA NIH HHS/United States
GR  - T32 AA014127-05/AA/NIAAA NIH HHS/United States
GR  - 1T32AA014127/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Complementary)
RN  - 0 (RNA, Messenger)
RN  - 3K9958V90M (Ethanol)
RN  - EC 2.4.2.8 (Hypoxanthine Phosphoribosyltransferase)
RN  - EC 5.2.1.- (Cyclophilin A)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Brain Chemistry/drug effects/*physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Central Nervous System Depressants/blood
MH  - Cyclophilin A/metabolism
MH  - DNA Primers
MH  - DNA, Complementary/biosynthesis/genetics
MH  - Depressive Disorder/etiology/*metabolism/*psychology
MH  - Ethanol/blood
MH  - Exons/genetics
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/*metabolism/*psychology
MH  - Helplessness, Learned
MH  - Hypoxanthine Phosphoribosyltransferase/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Motor Activity/drug effects
MH  - Pregnancy
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Swimming/psychology
PMC - PMC2762406
MID - NIHMS149171
EDAT- 2008/06/19 09:00
MHDA- 2008/12/17 09:00
PMCR- 2009/10/15
CRDT- 2008/06/19 09:00
PHST- 2008/02/21 00:00 [received]
PHST- 2008/05/05 00:00 [revised]
PHST- 2008/05/09 00:00 [accepted]
PHST- 2008/06/19 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/06/19 09:00 [entrez]
PHST- 2009/10/15 00:00 [pmc-release]
AID - S0091-3057(08)00155-X [pii]
AID - 10.1016/j.pbb.2008.05.004 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2008 Oct;90(4):614-24. doi: 10.1016/j.pbb.2008.05.004.