PMID- 18559655
OWN - NLM
STAT- MEDLINE
DCOM- 20081118
LR  - 20230411
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 31
IP  - 9
DP  - 2008 Sep
TI  - Association of brominated flame retardants with diabetes and metabolic syndrome 
      in the U.S. population, 2003-2004.
PG  - 1802-7
LID - 10.2337/dc08-0850 [doi]
AB  - OBJECTIVE: Chlorinated persistent organic pollutants (POPs), endocrine disruptors 
      accumulated in adipose tissue, were associated with diabetes and metabolic 
      syndrome. Brominated flame retardants (BFRs), such as polybrominated diphenyl 
      ethers (PBDEs) or polybrominated biphenyls (PBBs), are another class of POPs for 
      which body burden is increasing. Cross-sectional associations of serum 
      concentrations of BFRs with diabetes and metabolic syndrome were studied. 
      RESEARCH DESIGN AND METHODS: In the National Health and Nutrition Examination 
      Survey 2003-2004, 1,367 adults were examined with respect to diabetes status. 
      Five PBDEs and one PBB were selected, detectable in >or=60% of participants. For 
      the outcome metabolic syndrome, we restricted the analysis to 637 participants 
      with a morning fasting sample. RESULTS: Compared with subjects with serum 
      concentrations below the limit of detection, prevalent diabetes had differing 
      dose-response associations with serum concentrations of PBB-153 and PBDE-153. 
      Adjusted odds ratios across quartiles of serum concentrations for PBB-153 or 
      PBDE-153 were 1.0, 0.7, 1.4, 1.6, and 1.9 (P for trend <0.01) and 1.0, 1.6, 2.6, 
      2.7, and 1.8 (P for quadratic term <0.01), respectively. PBB-153 was also 
      positively associated with the prevalence of metabolic syndrome with adjusted 
      odds ratios of 1.0, 1.5, 3.1, 3.1, and 3.1 (P for trend<0.01). As in its 
      association with diabetes, PBDE-153 showed an inverted U-shaped association with 
      metabolic syndrome. CONCLUSIONS: Pending confirmation in prospective studies, 
      lipophilic xenobiotics, including brominated POPs stored in adipose tissue, may 
      be involved in the pathogenesis of diabetes and metabolic syndrome.
FAU - Lim, Ji-Sun
AU  - Lim JS
AD  - Department of Preventive Medicine and Health Promotion Research Center, School of 
      Medicine, Kyungpook National University, Daegu, Korea.
FAU - Lee, Duk-Hee
AU  - Lee DH
FAU - Jacobs, David R Jr
AU  - Jacobs DR Jr
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080616
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Flame Retardants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Phenyl Ethers)
RN  - 0 (Polybrominated Biphenyls)
RN  - 6V3EKB2B9Z (2,2',3,4',5',6-hexabromobiphenyl)
RN  - NX58WCQ511 (2,2',4,4',5,5'-hexabrominated diphenyl ether)
SB  - IM
MH  - Adipose Tissue/drug effects
MH  - Centers for Disease Control and Prevention, U.S.
MH  - Diabetes Mellitus/*chemically induced/*epidemiology
MH  - Dose-Response Relationship, Drug
MH  - Flame Retardants/*toxicity
MH  - Halogenated Diphenyl Ethers
MH  - Humans
MH  - Hydrocarbons, Chlorinated/toxicity
MH  - Metabolic Syndrome/*chemically induced/*epidemiology
MH  - Odds Ratio
MH  - Phenyl Ethers/blood/*toxicity
MH  - Polybrominated Biphenyls/blood/*toxicity
MH  - United States/epidemiology
PMC - PMC2518348
EDAT- 2008/06/19 09:00
MHDA- 2008/11/19 09:00
PMCR- 2009/09/01
CRDT- 2008/06/19 09:00
PHST- 2008/06/19 09:00 [pubmed]
PHST- 2008/11/19 09:00 [medline]
PHST- 2008/06/19 09:00 [entrez]
PHST- 2009/09/01 00:00 [pmc-release]
AID - dc08-0850 [pii]
AID - 3191802 [pii]
AID - 10.2337/dc08-0850 [doi]
PST - ppublish
SO  - Diabetes Care. 2008 Sep;31(9):1802-7. doi: 10.2337/dc08-0850. Epub 2008 Jun 16.