PMID- 18560802
OWN - NLM
STAT- MEDLINE
DCOM- 20081118
LR  - 20221207
IS  - 0012-186X (Print)
IS  - 0012-186X (Linking)
VI  - 51
IP  - 8
DP  - 2008 Aug
TI  - A cross-sectional study of the association between persistent organic pollutants 
      and glucose intolerance among Greenland Inuit.
PG  - 1416-22
LID - 10.1007/s00125-008-1066-0 [doi]
AB  - AIMS/HYPOTHESIS: Some evidence supports the hypothesis that persistent organic 
      pollutants (POPs) may increase the risk of type 2 diabetes. The Inuit population 
      in Greenland, which is highly exposed to POPs due to a high intake of marine 
      mammals, has experienced a rapid increase in diabetes prevalence over the last 30 
      years. Thus the aim was to study the association between POPs and glucose 
      intolerance and markers of insulin resistance and insulin secretion using a 
      population-based design. METHODS: From 1999 to 2002 the Greenland population 
      study was carried out among adult Inuit living in Greenland. The examination 
      included a 75 g OGTT, anthropometric measurements, a structured interview, and 
      blood tests. Plasma glucose and serum insulin were analysed, and three defined 
      subclasses of POPs were analysed in a subgroup. Associations were adjusted for 
      age, sex, waist circumference, Inuit heritage, cigarette smoking, alcohol 
      consumption and educational level. RESULTS: Data on POPs were available on 692 
      individuals, 305 men (mean age 50 years) and 387 women (mean age 49 years). The 
      prevalence of diabetes was 10.3%, and 10.5% had impaired glucose tolerance. The 
      concentrations of several POPs were exceptionally high. While no associations 
      were found between POPs and stages of glucose intolerance or markers of insulin 
      resistance, POPs were significantly inversely associated with stimulated insulin 
      concentrations and homeostasis model assessment of beta cell function. 
      CONCLUSIONS/INTERPRETATION: The study indicates that POPs may affect insulin 
      secretion rather than being involved in the pathogenesis of insulin resistance. 
      No association was seen between POPs and glucose intolerance or markers of 
      insulin resistance.
FAU - Jorgensen, M E
AU  - Jorgensen ME
AD  - Steno Diabetes Center, Gentofte, Denmark. Mej@niph.dk
FAU - Borch-Johnsen, K
AU  - Borch-Johnsen K
FAU - Bjerregaard, P
AU  - Bjerregaard P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080617
PL  - Germany
TA  - Diabetologia
JT  - Diabetologia
JID - 0006777
RN  - 0 (Air Pollutants)
RN  - 0 (Dioxins)
RN  - 0 (Organic Chemicals)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Air Pollutants/*adverse effects
MH  - Cross-Sectional Studies
MH  - Dioxins/adverse effects/analysis
MH  - Glucose Intolerance/*epidemiology/etiology
MH  - Glucose Tolerance Test
MH  - Greenland/epidemiology
MH  - Humans
MH  - Inuit/*statistics & numerical data
MH  - Organic Chemicals/*adverse effects
MH  - Polychlorinated Biphenyls/adverse effects/analysis
EDAT- 2008/06/19 09:00
MHDA- 2008/11/19 09:00
CRDT- 2008/06/19 09:00
PHST- 2007/12/27 00:00 [received]
PHST- 2008/05/08 00:00 [accepted]
PHST- 2008/06/19 09:00 [pubmed]
PHST- 2008/11/19 09:00 [medline]
PHST- 2008/06/19 09:00 [entrez]
AID - 10.1007/s00125-008-1066-0 [doi]
PST - ppublish
SO  - Diabetologia. 2008 Aug;51(8):1416-22. doi: 10.1007/s00125-008-1066-0. Epub 2008 
      Jun 17.