PMID- 18562036
OWN - NLM
STAT- MEDLINE
DCOM- 20081008
LR  - 20181201
IS  - 1873-4995 (Electronic)
IS  - 0168-3659 (Linking)
VI  - 129
IP  - 3
DP  - 2008 Aug 7
TI  - A novel preparation method for PLGA microspheres using non-halogenated solvents.
PG  - 223-7
LID - 10.1016/j.jconrel.2008.04.008 [doi]
AB  - We investigated a new preparation method for microspheres based on an Oil/Water 
      type emulsion solvent evaporation method using non-halogenated solvents. This 
      method is based on phase separation between acetone and aqueous glycerol. For the 
      preparation of microspheres by this method, a solution of 
      poly(DL-lactic-co-glycolic acid) (PLGA) in acetone and aqueous glycerol 
      containing poly(vinyl alcohol) were used asthe dispersed and continuous phases in 
      the emulsification process, respectively. Vitamin B12 was used as the model drug. 
      The formation of PLGA microspheres was observed above 60% glycerol in the 
      continuous phase. The yield and encapsulation efficiency of the PLGA microspheres 
      was about 80%, which was the maximum yield obtained with 70% glycerol. The 
      release of vitamin B12 lasted for three weeks.
FAU - Matsumoto, Akihiro
AU  - Matsumoto A
AD  - Tanabe Seiyaku Co. Ltd., 2-10, Dosho-machi 3-chome, Chuo-ku, Osaka 541-8505, 
      Japan. matsumoto.akihiro@mf.mt-pharma.co.jp
FAU - Kitazawa, Takeo
AU  - Kitazawa T
FAU - Murata, Junichi
AU  - Murata J
FAU - Horikiri, Yuji
AU  - Horikiri Y
FAU - Yamahara, Hiroshi
AU  - Yamahara H
LA  - eng
PT  - Journal Article
DEP - 20080422
PL  - Netherlands
TA  - J Control Release
JT  - Journal of controlled release : official journal of the Controlled Release 
      Society
JID - 8607908
RN  - 0 (Emulsions)
RN  - 0 (Oils)
RN  - 0 (Solvents)
RN  - 059QF0KO0R (Water)
RN  - 1364PS73AF (Acetone)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 9002-89-5 (Polyvinyl Alcohol)
RN  - P6YC3EG204 (Vitamin B 12)
RN  - PDC6A3C0OX (Glycerol)
SB  - IM
MH  - Acetone/*chemistry
MH  - Emulsions
MH  - Glycerol/*chemistry
MH  - Lactic Acid/*chemistry
MH  - *Microspheres
MH  - Molecular Weight
MH  - Oils/chemistry
MH  - Particle Size
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polyvinyl Alcohol/chemistry
MH  - Solvents/*chemistry
MH  - Vitamin B 12/pharmacokinetics/pharmacology
MH  - Water/chemistry
EDAT- 2008/06/20 09:00
MHDA- 2008/10/09 09:00
CRDT- 2008/06/20 09:00
PHST- 2007/09/30 00:00 [received]
PHST- 2008/03/29 00:00 [revised]
PHST- 2008/04/06 00:00 [accepted]
PHST- 2008/06/20 09:00 [pubmed]
PHST- 2008/10/09 09:00 [medline]
PHST- 2008/06/20 09:00 [entrez]
AID - S0168-3659(08)00188-0 [pii]
AID - 10.1016/j.jconrel.2008.04.008 [doi]
PST - ppublish
SO  - J Control Release. 2008 Aug 7;129(3):223-7. doi: 10.1016/j.jconrel.2008.04.008. 
      Epub 2008 Apr 22.