PMID- 18564361
OWN - NLM
STAT- MEDLINE
DCOM- 20081216
LR  - 20151119
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 142
IP  - 4
DP  - 2008 Aug
TI  - Delineation of distinct tumour profiles in mantle cell lymphoma by detailed 
      cytogenetic, interphase genetic and morphological analysis.
PG  - 538-50
LID - 10.1111/j.1365-2141.2008.07199.x [doi]
AB  - Mantle cell lymphoma (MCL) is an aggressive lymphoid tumour characterized by the 
      translocation t(11;14)(q13;q32) and a poor clinical outcome (median survival: 3-4 
      years). Recent studies revealed that increased proliferation of the tumour cells 
      and certain chromosomal aberrations, such as deletions of 17p13 and 9p21 
      represent major adverse biological markers in this disease, although the 
      molecular targets of chromosomal imbalances in MCL have not been identified for 
      the large majority of loci affected. To correlate histomorphological and 
      proliferation features of MCL with genetic findings, we investigated 223 MCL by 
      fluorescence in situ hybridization (FISH) (n = 157) and/or classical cytogenetic 
      banding analysis (n = 129). FISH analysis turned out to be distinctly more 
      sensitive in the delineation of aberrations. Complex karyotypic alterations were 
      associated with higher proliferation indices and inferior prognosis. A 
      comprehensive analysis of biological features including genetic alterations in 
      MCL by hierarchical clustering resulted in the delineation of four tumour 
      subgroups differing with respect to their genetic constitution and suggesting 
      different transformation or progression pathways. Moreover, in one of the groups 
      identified, a more indolent clinical behaviour was associated with few secondary 
      aberrations and fewer known high-risk chromosomal aberrations, which points to 
      the importance of the quality of karyotypic evolution in MCL tumours.
FAU - Katzenberger, Tiemo
AU  - Katzenberger T
AD  - Department of Pathology, University of Wurzburg, Germany.
FAU - Kienle, Dirk
AU  - Kienle D
FAU - Stilgenbauer, Stephan
AU  - Stilgenbauer S
FAU - Holler, Sylvia
AU  - Holler S
FAU - Schilling, Carolin
AU  - Schilling C
FAU - Mader, Uwe
AU  - Mader U
FAU - Puppe, Bernhard
AU  - Puppe B
FAU - Petzoldt, Celine
AU  - Petzoldt C
FAU - Sander, Sandrine
AU  - Sander S
FAU - Bullinger, Lars
AU  - Bullinger L
FAU - Stocklein, Heike
AU  - Stocklein H
FAU - Kalla, Jorg
AU  - Kalla J
FAU - Hartmann, Elena
AU  - Hartmann E
FAU - Adam, Patrick
AU  - Adam P
FAU - Ott, M Michaela
AU  - Ott MM
FAU - Muller-Hermelink, Hans-Konrad
AU  - Muller-Hermelink HK
FAU - Rosenwald, Andreas
AU  - Rosenwald A
FAU - Ott, German
AU  - Ott G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080628
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Antigens, CD)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, CD/blood
MH  - Biomarkers, Tumor/blood
MH  - Cytogenetics
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Interphase/*genetics
MH  - Lymphoma, Mantle-Cell/*genetics/immunology/mortality
MH  - Male
MH  - Middle Aged
MH  - Survival Analysis
MH  - Translocation, Genetic
MH  - Tumor Suppressor Protein p53/metabolism
EDAT- 2008/06/20 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/06/20 09:00
PHST- 2008/06/20 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/06/20 09:00 [entrez]
AID - BJH7199 [pii]
AID - 10.1111/j.1365-2141.2008.07199.x [doi]
PST - ppublish
SO  - Br J Haematol. 2008 Aug;142(4):538-50. doi: 10.1111/j.1365-2141.2008.07199.x. 
      Epub 2008 Jun 28.