PMID- 1856486
OWN - NLM
STAT- MEDLINE
DCOM- 19910823
LR  - 20190510
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 164
IP  - 2
DP  - 1991 Aug
TI  - Characteristics of experimental Candida albicans infection of the central nervous 
      system in rabbits.
PG  - 389-95
AB  - Different concentrations (10(7), 10(5), 10(3) cfu/ml) of Candida albicans were 
      injected intracisternally in rabbits. The highest inoculum was fatal within 14 h 
      in all animals. In recipients of 10(5) and 10(3) cfu/ml inocula, the mean +/- SD 
      peak cerebrospinal fluid (CSF) tumor necrosis factor-alpha (TNF alpha) 
      concentrations were 1.6 +/- 2.42 and 0.3 +/- 0.59 ng/ml, respectively, at 6 h; 
      the mean +/- SD CSF leukocyte and protein concentrations were 6291 +/- 6515 and 
      453 +/- 674 cells/mm3 (at 24 h) and 118 +/- 90 and 109 +/- 122 mg/dl (at 12 and 
      24 h), respectively. At 6-10 days after inoculation, a second peak of TNF alpha 
      activity was accompanied by increased CSF inflammation. Mortality in the 10(5) 
      and 10(3) cfu/ml inoculum groups was 56% and 22%, respectively. Fatal infection 
      was associated with higher second CSF peak TNF alpha and leukocyte concentrations 
      and a larger proportion of culture-positive CSF samples. Histopathology revealed 
      hyphal invasion, vasculitis, abscesses, and acute and chronic inflammatory 
      infiltration of meninges and brain parenchyma. This model can be useful for 
      evaluation of the pathogenesis and therapy of central nervous system fungal 
      infections.
FAU - Jafari, H S
AU  - Jafari HS
AD  - Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 
      75235-9063.
FAU - Saez-Llorens, X
AU  - Saez-Llorens X
FAU - Grimprel, E
AU  - Grimprel E
FAU - Argyle, J C
AU  - Argyle JC
FAU - Olsen, K D
AU  - Olsen KD
FAU - McCracken, G H Jr
AU  - McCracken GH Jr
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Cerebrospinal Fluid Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Brain/pathology
MH  - Brain Diseases/*cerebrospinal fluid/pathology
MH  - Candida albicans/isolation & purification
MH  - Candidiasis/*cerebrospinal fluid/pathology
MH  - Cerebrospinal Fluid/cytology/microbiology
MH  - Cerebrospinal Fluid Proteins/analysis
MH  - Disease Models, Animal
MH  - Leukocyte Count
MH  - Male
MH  - Meninges/pathology
MH  - Meningitis/*cerebrospinal fluid/pathology
MH  - Rabbits
MH  - Tumor Necrosis Factor-alpha/cerebrospinal fluid
EDAT- 1991/08/11 19:15
MHDA- 2001/03/28 10:01
CRDT- 1991/08/11 19:15
PHST- 1991/08/11 19:15 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1991/08/11 19:15 [entrez]
AID - 10.1093/infdis/164.2.389 [doi]
PST - ppublish
SO  - J Infect Dis. 1991 Aug;164(2):389-95. doi: 10.1093/infdis/164.2.389.