PMID- 18565516
OWN - NLM
STAT- MEDLINE
DCOM- 20090708
LR  - 20220321
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 91
IP  - 6
DP  - 2009 Jun
TI  - Prevalence of human herpes virus types 1-7 in the semen of men attending an 
      infertility clinic and correlation with semen parameters.
PG  - 2487-94
LID - 10.1016/j.fertnstert.2008.03.074 [doi]
AB  - OBJECTIVE: To determine the prevalence of herpes viruses in the semen of an 
      asymptomatic male cohort with and without infertility problems and its 
      association with altered semen parameters. DESIGN: A prospective randomized 
      study. SETTING: Medical school and IVF clinic. PATIENT(S): One hundred 
      seventy-two male patients undergoing routine semen analysis: 80 with normal semen 
      parameters (control group) and 92 with abnormal semen parameters. 
      INTERVENTION(S): Semen samples were collected by masturbation. MAIN OUTCOME 
      MEASURE(S): The DNA from the Herpesviridae family (herpes simplex virus 1 
      [HSV-1], herpes simplex virus 2 [HSV-2], Varicella zoster virus [VZV], 
      Epstein-Barr virus [EBV], cytomegalovirus [CMV], human herpes virus type 6 
      [HHV-6], human herpes virus type 7 [HHV-7]) and routine semen parameters. 
      RESULT(S): Viral DNA was detected in 143/172 (83.1%) of the total samples for at 
      least one herpes virus: HSV-1, 2.5%; VZV, 1.2%; EBV, 45%; CMV, 62.5%; HHV-6, 70%; 
      HHV-7, 0% in the normal semen samples and HSV-1, 2.1%; VZV, 3.2%; EBV, 39.1%; 
      CMV, 56.5%; HHV-6, 66.3%; HHV-7, 0% in the abnormal semen samples. No association 
      was found between the presence of viral DNA and semen parameters. Interestingly, 
      a statistical significance between leukocytospermia and the presence of EBV DNA 
      was observed. CONCLUSION(S): The DNA of herpes viruses is frequently detected in 
      the semen of asymptomatic fertile and infertile male patients. Further studies 
      are required to investigate the role of herpes viruses in male factor 
      infertility.
FAU - Neofytou, Eirini
AU  - Neofytou E
AD  - Laboratory of Human Reproduction, IVF Clinic, Department of Obstetrics and 
      Gynecology, Faculty of Medicine, University of Crete, Crete, Greece.
FAU - Sourvinos, George
AU  - Sourvinos G
FAU - Asmarianaki, Maria
AU  - Asmarianaki M
FAU - Spandidos, Demetrios A
AU  - Spandidos DA
FAU - Makrigiannakis, Antonios
AU  - Makrigiannakis A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080618
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Azoospermia/virology
MH  - Cytomegalovirus/*isolation & purification
MH  - DNA, Viral/genetics/isolation & purification
MH  - Fertilization in Vitro
MH  - Herpesvirus 1, Human/*isolation & purification
MH  - Herpesvirus 2, Human/*isolation & purification
MH  - Herpesvirus 3, Human/genetics/*isolation & purification
MH  - Herpesvirus 4, Human/genetics/*isolation & purification
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Herpesvirus 7, Human/*isolation & purification
MH  - Humans
MH  - Infertility, Male/*physiopathology/virology
MH  - Male
MH  - Masturbation
MH  - Oligospermia/virology
MH  - Reference Values
MH  - Semen/*virology
EDAT- 2008/06/21 09:00
MHDA- 2009/07/09 09:00
CRDT- 2008/06/21 09:00
PHST- 2008/03/03 00:00 [received]
PHST- 2008/03/28 00:00 [revised]
PHST- 2008/03/28 00:00 [accepted]
PHST- 2008/06/21 09:00 [pubmed]
PHST- 2009/07/09 09:00 [medline]
PHST- 2008/06/21 09:00 [entrez]
AID - S0015-0282(08)00749-8 [pii]
AID - 10.1016/j.fertnstert.2008.03.074 [doi]
PST - ppublish
SO  - Fertil Steril. 2009 Jun;91(6):2487-94. doi: 10.1016/j.fertnstert.2008.03.074. 
      Epub 2008 Jun 18.