PMID- 18565553
OWN - NLM
STAT- MEDLINE
DCOM- 20090421
LR  - 20131121
IS  - 0034-5288 (Print)
IS  - 0034-5288 (Linking)
VI  - 86
IP  - 1
DP  - 2009 Feb
TI  - Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar 
      epithelial type II cells.
PG  - 78-87
LID - 10.1016/j.rvsc.2008.05.009 [doi]
AB  - Leukotrienes (LT) and chemokines are important chemotactic compounds in 
      regulating the recruitment and activation of immune cells during pulmonary 
      inflammatory reactions. Results showed that LTC4 release by porcine alveolar 
      epithelial type II cells (AEC IIs) is significantly enhanced by either LTB4 or 
      LPS stimulation. The basal level of IL-8 gene expression in AEC IIs was only 1/3 
      of that observed in alveolar macrophages (AMs) while AEC IIs expressed a higher 
      basal level of monocyte chemotactic peptide-1 (MCP-1) and also in response to LPS 
      stimulation than do AMs. The increasing basal and LT-induced MCP-1 gene 
      expressions after 8h of incubation were observed in AEC IIs but decreased in AMs. 
      These findings suggest that AEC IIs play an important role in initial 
      inflammatory reactions of the lung by releasing LTC4, and that they also modulate 
      later inflammatory reactions, evidenced by consistent elevation of MCP-1 gene 
      expression after and during exogenous challenge in pigs.
FAU - Chaung, Hso-Chi
AU  - Chaung HC
AD  - Department of Veterinary Medicine, National Pingtung University of Science and 
      Technology, 1 Hsueh Fu Road, Nei Pu Hsiang, 91207 Pingtung, Taiwan, ROC. 
      hcchaung@mail.npust.edu.tw
FAU - Lien, Yi
AU  - Lien Y
FAU - Chung, Wen-Bin
AU  - Chung WB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080618
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-8)
RN  - 0 (RNA, Messenger)
RN  - 2CU6TT9V48 (Leukotriene C4)
SB  - IM
MH  - Animals
MH  - Cell Communication/immunology
MH  - Chemokine CCL2/*biosynthesis/genetics
MH  - Enzyme-Linked Immunosorbent Assay/veterinary
MH  - Gene Expression
MH  - Interleukin-8/*biosynthesis/genetics
MH  - Leukotriene C4/*biosynthesis
MH  - Macrophages, Alveolar/immunology/pathology
MH  - Male
MH  - Pneumonia/immunology/*veterinary
MH  - Pulmonary Alveoli/*immunology/pathology
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction/veterinary
MH  - Swine
MH  - Swine Diseases/*immunology
EDAT- 2008/06/21 09:00
MHDA- 2009/04/22 09:00
CRDT- 2008/06/21 09:00
PHST- 2007/12/20 00:00 [received]
PHST- 2008/05/09 00:00 [revised]
PHST- 2008/05/12 00:00 [accepted]
PHST- 2008/06/21 09:00 [pubmed]
PHST- 2009/04/22 09:00 [medline]
PHST- 2008/06/21 09:00 [entrez]
AID - S0034-5288(08)00114-8 [pii]
AID - 10.1016/j.rvsc.2008.05.009 [doi]
PST - ppublish
SO  - Res Vet Sci. 2009 Feb;86(1):78-87. doi: 10.1016/j.rvsc.2008.05.009. Epub 2008 Jun 
      18.