PMID- 18565744
OWN - NLM
STAT- MEDLINE
DCOM- 20090204
LR  - 20211028
IS  - 0936-6555 (Print)
IS  - 1433-2981 (Electronic)
IS  - 0936-6555 (Linking)
VI  - 20
IP  - 8
DP  - 2008 Oct
TI  - Accuracy and reproducibility of conformal radiotherapy using data from a 
      randomised controlled trial of conformal radiotherapy in prostate cancer (MRC 
      RT01, ISRCTN47772397).
PG  - 582-90
LID - 10.1016/j.clon.2008.04.019 [doi]
AB  - AIMS: The MRC RT01 trial used conformal radiotherapy to the prostate, a method 
      that reduces the volume of normal tissue treated by 40-50%. Because of the risk 
      of geographical miss, the trial used portal imaging to examine whether treatment 
      delivery was within the required accuracy. MATERIAL AND METHODS: In total, 843 
      patients were randomly assigned to receive 64 Gy in 32 fractions over 6.5 weeks 
      or 74 Gy in 37 fractions over 7.5 weeks. Field displacements and corrections were 
      recorded for all imaged fractions. Displacement trends and their association with 
      time, disease and treatment set-up characteristics were examined using univariate 
      and multivariate analyses. A Radiographer Trial Implementation Group (RTIG) was 
      set up to inform the quality assurance process and to promote the development of 
      best practice. RESULTS: Treatment isocentre positioning was within 5 mm in every 
      direction on 6238 (83%) of the 7535 fractions imaged. In total, 532 (81%) of 695 
      included patients had at least one > or = 3 mm displacement and 415 (63%) had at 
      least one > or = 5 mm displacement. Univariate, multivariate and stepwise models 
      of > or =5 mm displacements showed an increased likelihood of displacement in 
      weeks 1 and 2 with low melting point alloy (LMPA) blocks compared with multileaf 
      collimators, film verification compared with electronic portal imaging (EPI) and 
      increased number of fractions imaged. Except for LMPA, this was also seen for > 
      or = 5 mm displacements in weeks 3-6. CONCLUSIONS: Accurate conformal treatment 
      was delivered. The use of EPI was associated with increased reported accuracy. 
      The RTIG was a crucial part of the quality assurance process.
FAU - Stanley, S
AU  - Stanley S
AD  - St James's Institute of Oncology, Leeds, UK. suzanne.stanley@leedsth.nhs.uk
FAU - Griffiths, S
AU  - Griffiths S
FAU - Sydes, M R
AU  - Sydes MR
FAU - Moore, A R
AU  - Moore AR
FAU - Syndikus, I
AU  - Syndikus I
FAU - Dearnaley, D P
AU  - Dearnaley DP
CN  - RT01 Radiographer Trial Implementation Group
LA  - eng
SI  - ISRCTN/ISRCTN47772397
GR  - G0501019/MRC_/Medical Research Council/United Kingdom
GR  - MC_U122861330/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20080618
PL  - England
TA  - Clin Oncol (R Coll Radiol)
JT  - Clinical oncology (Royal College of Radiologists (Great Britain))
JID - 9002902
SB  - IM
MH  - Adenocarcinoma/*radiotherapy
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Prostatic Neoplasms/*radiotherapy
MH  - Quality Assurance, Health Care
MH  - Radiotherapy, Conformal/*methods
MH  - Reproducibility of Results
PMC - PMC2568874
EDAT- 2008/06/21 09:00
MHDA- 2009/02/05 09:00
PMCR- 2008/10/01
CRDT- 2008/06/21 09:00
PHST- 2007/03/05 00:00 [received]
PHST- 2008/04/08 00:00 [revised]
PHST- 2008/04/10 00:00 [accepted]
PHST- 2008/06/21 09:00 [pubmed]
PHST- 2009/02/05 09:00 [medline]
PHST- 2008/06/21 09:00 [entrez]
PHST- 2008/10/01 00:00 [pmc-release]
AID - S0936-6555(08)00253-7 [pii]
AID - 10.1016/j.clon.2008.04.019 [doi]
PST - ppublish
SO  - Clin Oncol (R Coll Radiol). 2008 Oct;20(8):582-90. doi: 
      10.1016/j.clon.2008.04.019. Epub 2008 Jun 18.