PMID- 18566557
OWN - NLM
STAT- MEDLINE
DCOM- 20090210
LR  - 20211203
IS  - 1425-9524 (Print)
IS  - 1425-9524 (Linking)
VI  - 13
IP  - 2
DP  - 2008
TI  - Human leukocyte antigen (HLA) B-27 and older age are associated with augmented 
      cyclosporine blood bioavailability in renal allograft recipients: an attempt 
      toward individualization of immunosuppression.
PG  - 32-6
AB  - BACKGROUND: Therapeutic drug monitoring of cyclosporine (CsA) blood values in 
      renal transplant recipients is of extreme importance; hence, finding contributing 
      factors in this issue is relevant. In this study, we aimed to evaluate potential 
      associations of some characteristics of the recipients including their human 
      leukocyte antigen haplotypes with their drug bioavailability. MATERIAL/METHODS: 
      616 patients who had a valid HLA typing result concomitant with other demographic 
      data in our local data registry were consecutively selected. We extracted their 
      HLA typing, age, gender, weight, cause of renal failure, first measured CsA 
      trough level (C0) and concomitantly measured creatinine, CsA administered dosage, 
      time duration from transplantation, routine laboratory test results, panel 
      reactive antibodies percentage, and immunosuppression type. Bivariate and 
      multivariate linear regressions were employed to evaluate associations of these 
      factors with blood C0 values. RESULTS: 64.5% of patients were male. Mean age at 
      transplantation was 40.7+/-15.8. Mean first measured C0 was 271+/-178 ng/ml. 
      Analysis showed that the only factors which had independent association with C0 
      were age at transplantation, dose/weight ratio and HLA-B27. CONCLUSIONS: genetic 
      factors as well as age of patients are two founded factors in this study which 
      are recommended to be considered in monitoring drug administration in organ 
      transplant recipients.
FAU - Nemati, Eghlim
AU  - Nemati E
AD  - Nephrology & Urology Research Center (NURC), Tehran, Iran. nemati203@gmail.com
FAU - Taheri, Saeed
AU  - Taheri S
FAU - Pourfarziani, Vahid
AU  - Pourfarziani V
FAU - Einollahi, Behzad
AU  - Einollahi B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Transplant
JT  - Annals of transplantation
JID - 9802544
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (Immunosuppressive Agents)
RN  - 83HN0GTJ6D (Cyclosporine)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Biological Availability
MH  - Cohort Studies
MH  - Cyclosporine/administration & dosage/*pharmacokinetics
MH  - Female
MH  - HLA-B27 Antigen
MH  - Humans
MH  - Immunosuppression Therapy
MH  - Immunosuppressive Agents/administration & dosage/*pharmacokinetics
MH  - Iran
MH  - Kidney Failure, Chronic/*blood/etiology/*surgery
MH  - *Kidney Transplantation
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 2008/06/21 09:00
MHDA- 2009/02/12 09:00
CRDT- 2008/06/21 09:00
PHST- 2008/04/29 00:00 [accepted]
PHST- 2008/03/25 00:00 [received]
PHST- 2008/06/21 09:00 [pubmed]
PHST- 2009/02/12 09:00 [medline]
PHST- 2008/06/21 09:00 [entrez]
AID - 858104 [pii]
PST - ppublish
SO  - Ann Transplant. 2008;13(2):32-6.