PMID- 18567875
OWN - NLM
STAT- MEDLINE
DCOM- 20080908
LR  - 20080623
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1132
DP  - 2008
TI  - Immunosuppression of EAMG by IVIG is mediated by a disease-specific 
      anti-immunoglobulin fraction.
PG  - 244-8
LID - 10.1196/annals.1405.032 [doi]
AB  - Intravenous immunoglobulin (IVIG) administration has been beneficially used for 
      the treatment of a variety of autoimmune diseases including myasthenia gravis 
      (MG). We have demonstrated that IVIG administration in experimental autoimmune MG 
      (EAMG) results in suppression of disease that is accompanied by decreased Th1 
      cell and B cell proliferation. Chromatography of pooled human immunoglobulins 
      (IVIG) on immobilized IgG, isolated from rats with EAMG or from MG patients, 
      results in a depletion of the suppressive activity of the IVIG. Moreover, 
      reconstitution of the activity-depleted IVIG with the eluted minute IVIG 
      fractions that had been adsorbed onto the EAMG- or MG-specific columns recovers 
      the depleted immunosuppressive activity. This study supports the notion that the 
      therapeutic effect of IVIG is mediated by an antigen-specific anti-immunoglobulin 
      (anti-idiotypic) activity that is essential for its suppressive activity.
FAU - Fuchs, Sara
AU  - Fuchs S
AD  - Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, 
      Israel. sara.fuchs@weizmann.ac.il
FAU - Feferman, Tali
AU  - Feferman T
FAU - Meidler, Roberto
AU  - Meidler R
FAU - Margalit, Raanan
AU  - Margalit R
FAU - Sicsic, Camille
AU  - Sicsic C
FAU - Brenner, Talma
AU  - Brenner T
FAU - Laub, Orgad
AU  - Laub O
FAU - Souroujon, Miriam C
AU  - Souroujon MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Receptors, Cholinergic)
SB  - IM
MH  - Animals
MH  - Antibody Specificity/*immunology
MH  - Humans
MH  - Immunoglobulins, Intravenous/*immunology/*therapeutic use
MH  - Immunosuppressive Agents/*immunology/*therapeutic use
MH  - Immunotherapy
MH  - Myasthenia Gravis, Autoimmune, Experimental/*immunology/*therapy
MH  - Rats
MH  - Receptors, Cholinergic/immunology
EDAT- 2008/06/24 09:00
MHDA- 2008/09/09 09:00
CRDT- 2008/06/24 09:00
PHST- 2008/06/24 09:00 [pubmed]
PHST- 2008/09/09 09:00 [medline]
PHST- 2008/06/24 09:00 [entrez]
AID - 1132/1/244 [pii]
AID - 10.1196/annals.1405.032 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2008;1132:244-8. doi: 10.1196/annals.1405.032.