PMID- 18568574
OWN - NLM
STAT- MEDLINE
DCOM- 20081104
LR  - 20220409
IS  - 1748-2941 (Print)
IS  - 1748-2941 (Linking)
VI  - 10
IP  - 2
DP  - 2008
TI  - Oxidative stress and antioxidative defense parameters early after reperfusion 
      therapy for acute myocardial infarction.
PG  - 121-6
LID - 10.1080/17482940701744334 [doi]
AB  - Reperfusion of ischemic myocardium evokes rapid release of free radicals in 
      experimental models. The aim of the study was to investigate the oxidative stress 
      and antioxidative defense during first minutes after reopening of the infarct 
      related artery in patients treated for acute myocardial infarction. The study 
      group consisted of 15 patients with first ST elevation myocardial infarction 
      (STEMI) due to left anterior descending artery occlusion. The control group 
      included ten patients with stable ischemic heart disease (IHD). Blood samples 
      from coronary sinus were drawn before, immediately after and about 15 min after 
      angioplasty. Activity of superoxide dysmutase (SOD), concentration of glutathione 
      as well as the concentrations of lipid peroxides, malodialdehyde (MDA) and 
      4-hydroxy-2-nonenal (HNE) were measured. There was significantly higher 
      concentration of MDA and HNE and higher SOD activity in STEMI patients before the 
      reperfusion, as compared to the stable IHD group. After the reperfusion 
      concentration of HNE in erythrocytes from STEMI patients was higher than in IHD 
      group. At the same time the activity of SOD significantly decreased in patients 
      with impaired tissue perfusion (myocardial blush grade <2). In conclusion, there 
      is a slightly higher concentration of oxidative stress parameters in patients 
      with STEMI. Diminished antioxidative defense after reperfusion is associated with 
      impaired myocardial perfusion.
FAU - Kaminski, K
AU  - Kaminski K
AD  - Department of Cardiology, Medical University of Bialystok, Bialystok, Poland. 
      fizklin@mp.pl
FAU - Bonda, T
AU  - Bonda T
FAU - Wojtkowska, I
AU  - Wojtkowska I
FAU - Dobrzycki, S
AU  - Dobrzycki S
FAU - Kralisz, P
AU  - Kralisz P
FAU - Nowak, K
AU  - Nowak K
FAU - Prokopczuk, P
AU  - Prokopczuk P
FAU - Skrzydlewska, E
AU  - Skrzydlewska E
FAU - Kozuch, M
AU  - Kozuch M
FAU - Musial, W J
AU  - Musial WJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Acute Card Care
JT  - Acute cardiac care
JID - 101276603
RN  - 0 (Aldehydes)
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Lipid Peroxides)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
RN  - K1CVM13F96 (4-hydroxy-2-nonenal)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aldehydes/blood
MH  - Antioxidants/*metabolism
MH  - Biomarkers/*blood
MH  - Coronary Angiography
MH  - Electrocardiography
MH  - Follow-Up Studies
MH  - Glutathione/blood
MH  - Humans
MH  - Lipid Peroxides/blood
MH  - Malondialdehyde/blood
MH  - Middle Aged
MH  - Myocardial Infarction/*blood/diagnosis/therapy
MH  - Myocardial Reperfusion/*methods
MH  - *Oxidative Stress
MH  - Prognosis
MH  - Superoxide Dismutase/blood
EDAT- 2008/06/24 09:00
MHDA- 2008/11/05 09:00
CRDT- 2008/06/24 09:00
PHST- 2008/06/24 09:00 [pubmed]
PHST- 2008/11/05 09:00 [medline]
PHST- 2008/06/24 09:00 [entrez]
AID - 789053749 [pii]
AID - 10.1080/17482940701744334 [doi]
PST - ppublish
SO  - Acute Card Care. 2008;10(2):121-6. doi: 10.1080/17482940701744334.