PMID- 18568729
OWN - NLM
STAT- MEDLINE
DCOM- 20081113
LR  - 20080623
IS  - 0268-8697 (Print)
IS  - 0268-8697 (Linking)
VI  - 22
IP  - 3
DP  - 2008 Jun
TI  - Primitive neuroectodermal tumour arising within low grade astrocytoma: 
      transformation, de novo or radiation induced? Report of three cases and review of 
      literature.
PG  - 402-8
LID - 10.1080/02688690802056567 [doi]
AB  - The transformation from low grade to aggressive astrocytoma is well known. 
      However, the development of a completely different tumour such as a primitive 
      neuroectodermal tumour (PNET) within a low grade astrocytoma (LGA) is rare. Only 
      two cases have been reported to date. We present three cases and review the 
      literature. One case was identified at presentation. A subsequent review of our 
      histopathology database revealed two further cases. All three patients had 
      histologically proven low-grade astrocytoma and received radiotherapy following 
      biopsy. The tumour location was infratentorial in one and supratentorial in two. 
      The mean age at presentation with initial tumour was 20 years. Two patients 
      underwent partial resection for recurrence, one at five and the other ten years 
      later with histological confirmation of low-grade astrocytoma. At subsequent 
      recurrence eight and thirty years following original presentation and eleven 
      years later for the third patient, further tumour debulking was performed. 
      Histology now revealed high grade PNET. Cytogenetics showed a complex karyotype 
      with multiple chromosomal abnormalities in all three patients. All patients died 
      within 1 year of final surgery. Among the six reported cases of PNET arising 
      following prophylactic radiation therapy to low grade astrocytomas, only two 
      occurred within the original tumour. Whether these cases represent transformation 
      of low-grade astrocytoma, de novo formation of new tumour or radiation induced 
      neoplasm is uncertain.
FAU - Pal, D
AU  - Pal D
AD  - Department of Neurosurgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK. 
      debasishpal@yahoo.co.uk
FAU - Hall, G
AU  - Hall G
FAU - Loughrey, C
AU  - Loughrey C
FAU - Shivane, A
AU  - Shivane A
FAU - Chakrabarty, A
AU  - Chakrabarty A
FAU - Chumas, P
AU  - Chumas P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - England
TA  - Br J Neurosurg
JT  - British journal of neurosurgery
JID - 8800054
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Astrocytoma/etiology/*radiotherapy
MH  - Brain Neoplasms/etiology/*radiotherapy
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - Male
MH  - Neoplasm Recurrence, Local/etiology
MH  - Neoplasms, Radiation-Induced/*etiology
MH  - Neoplasms, Second Primary/*etiology
MH  - Neuroectodermal Tumors, Primitive/*etiology
RF  - 14
EDAT- 2008/06/24 09:00
MHDA- 2008/11/14 09:00
CRDT- 2008/06/24 09:00
PHST- 2008/06/24 09:00 [pubmed]
PHST- 2008/11/14 09:00 [medline]
PHST- 2008/06/24 09:00 [entrez]
AID - 793645347 [pii]
AID - 10.1080/02688690802056567 [doi]
PST - ppublish
SO  - Br J Neurosurg. 2008 Jun;22(3):402-8. doi: 10.1080/02688690802056567.