PMID- 18569377
OWN - NLM
STAT- MEDLINE
DCOM- 20080812
LR  - 20171116
IS  - 1547-6901 (Electronic)
IS  - 1547-691X (Linking)
VI  - 5
IP  - 2
DP  - 2008 Apr
TI  - Irritancy and sensitization potential of glyoxylic acid.
PG  - 93-8
LID - 10.1080/15476910802085681 [doi]
AB  - Glyoxylic acid, a small dicarboxylic acid, has been detected at measurable levels 
      in the atmosphere and is suspected to be present in indoor air environments. It 
      is generated through the ozonolysis of several high volume production compounds 
      that are commonly found indoors. Glyoxylic acid was tested in a combined 
      irritancy and local lymph node assay (LLNA). It tested positive in the LLNA with 
      an EC3 value of 5.05%. Significant increases were observed in the B220+cell 
      population in the draining lymph nodes. No changes were identified in the 
      IgE+B220+ cell population in the draining lymph nodes or total serum IgE levels; 
      this suggests that glyoxylic acid functions as a T-cell-mediated contact 
      sensitizer. Exposure to volatile organic compounds (VOC), similar to glyoxylic 
      acid, emitted from building materials, cleaning formulations or other consumer 
      products, and /or indoor chemistry have been linked to adverse health effects. 
      These results may provide an explanation for some of adverse health effects 
      associated with indoor air exposure.
FAU - Anderson, Stacey E
AU  - Anderson SE
AD  - National Institute for Occupational Safety and Health, Morgantown, West Virginia 
      26505, USA. sanderson4@cdc.gov
FAU - Ham, Jason E
AU  - Ham JE
FAU - Munson, Albert E
AU  - Munson AE
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Immunotoxicol
JT  - Journal of immunotoxicology
JID - 101201960
RN  - 0 (Glyoxylates)
RN  - 0 (Irritants)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
RN  - JQ39C92HH6 (glyoxylic acid)
SB  - IM
MH  - Air Pollution, Indoor/*adverse effects
MH  - Animals
MH  - Female
MH  - Glyoxylates/*toxicity
MH  - Immunoglobulin E/immunology
MH  - Irritants/*toxicity
MH  - Leukocyte Common Antigens/immunology
MH  - Lymph Nodes/*immunology/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - T-Lymphocytes/*immunology/pathology
MH  - *Toxicity Tests, Acute/methods
EDAT- 2008/06/24 09:00
MHDA- 2008/08/13 09:00
CRDT- 2008/06/24 09:00
PHST- 2008/06/24 09:00 [pubmed]
PHST- 2008/08/13 09:00 [medline]
PHST- 2008/06/24 09:00 [entrez]
AID - 793995088 [pii]
AID - 10.1080/15476910802085681 [doi]
PST - ppublish
SO  - J Immunotoxicol. 2008 Apr;5(2):93-8. doi: 10.1080/15476910802085681.