PMID- 18569567
OWN - NLM
STAT- MEDLINE
DCOM- 20080711
LR  - 20161124
IS  - 1528-7394 (Print)
IS  - 0098-4108 (Linking)
VI  - 71
IP  - 11-12
DP  - 2008
TI  - Polychlorinated dibenzo-p-dioxins/polychlorinated dibenzofurans (PCDD/Fs), 
      polychlorinated biphenyls (PCBs), and organochlorine pesticides in human blood of 
      pregnant women from Germany.
PG  - 703-9
LID - 10.1080/15287390801985034 [doi]
AB  - Blood samples from 226 pregnant women aged between 19 and 41 yr, living in an 
      industrialized area of Germany (Duisburg birth cohort study), were collected 
      between September 2000 and November 2002 and analyzed for their content of 
      persistent organic pollutants (POPs). Levels of polychlorinated dibenzo-p-dioxins 
      (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls 
      (PCBs) were in the range of 4.34-97.3 pg WHO 1998 TEq/g(lipid base) (median: 
      25.96) or 3.77-63.56 pg WHO 2005 TEq/g(lipid base) (median: 19.38), respectively. 
      Whole blood volume-based concentrations of organochlorine pesticides and their 
      metabolites were 0.036-0.53 microg/L (median: 0.15) hexachlorobenzene (HCB), 
      4.5-1300 ng/L (median: 67) beta-hexachlorocyclohexane (HCH), 0.6-520 ng/L 
      (median: 18) 4,4'-dichlorodiphenyltrichloroethane (DDT), and 0.1-9.1 microg/L 
      (median: 0.54) 4,4'-dichlorodiphenyldichloroethene (DDE). Parameters influencing 
      the POP levels in human blood were examined using multiple regression models. 
      Levels and the levels scatter widths of most PCDD/F and PCB congeners and HCB 
      increased significantly with age. Within the multiple regression model a weak age 
      dependence was also found for beta-HCH and DDT, whereas blood levels of alpha- 
      and gamma- HCH and DDE were not age dependent. The total lactation period for 
      earlier born children decreased most POP blood levels, except for alpha- and 
      gamma-HCH. Over the study period of 27 mo only a low decreasing effect on human 
      POP blood levels was observed. The body mass index had in general no or a low 
      positive influence on contaminant levels. Because exposure to PCDD/F and PCB is 
      higher in most industrialized countries in comparison to less industrialized 
      ones, lower levels of these substances were detected in blood samples of women 
      who had lived outside Western Europe for a longer period. In contrast, these 
      women showed higher blood levels of organochlorine pesticides, indicating that 
      these chemicals are still in use outside Western Europe.
FAU - Wittsiepe, Jurgen
AU  - Wittsiepe J
AD  - Department of Hygiene, Social and Environmental Medicine, Ruhr-University Bochum, 
      Bochum, Germany.
FAU - Schrey, Petra
AU  - Schrey P
FAU - Lemm, Friederike
AU  - Lemm F
FAU - Eberwein, Georg
AU  - Eberwein G
FAU - Wilhelm, Michael
AU  - Wilhelm M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Toxicol Environ Health A
JT  - Journal of toxicology and environmental health. Part A
JID - 100960995
RN  - 0 (Benzofurans)
RN  - 0 (Dibenzofurans, Polychlorinated)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Benzofurans/*blood
MH  - Blood Chemical Analysis
MH  - Dibenzofurans, Polychlorinated
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Pesticides/*blood
MH  - Polychlorinated Biphenyls/*blood
MH  - Polychlorinated Dibenzodioxins/*analogs & derivatives/blood
MH  - Pregnancy
EDAT- 2008/06/24 09:00
MHDA- 2008/07/12 09:00
CRDT- 2008/06/24 09:00
PHST- 2008/06/24 09:00 [pubmed]
PHST- 2008/07/12 09:00 [medline]
PHST- 2008/06/24 09:00 [entrez]
AID - 793808481 [pii]
AID - 10.1080/15287390801985034 [doi]
PST - ppublish
SO  - J Toxicol Environ Health A. 2008;71(11-12):703-9. doi: 10.1080/15287390801985034.