PMID- 18570703
OWN - NLM
STAT- MEDLINE
DCOM- 20090126
LR  - 20161020
IS  - 1461-1457 (Print)
IS  - 1461-1457 (Linking)
VI  - 11
IP  - 8
DP  - 2008 Dec
TI  - Housing conditions modulate escitalopram effects on antidepressive-like behaviour 
      and brain neurochemistry.
PG  - 1135-47
LID - 10.1017/S1461145708008912 [doi]
AB  - Despite limited understanding of the pathophysiology of depression and the 
      underlying mechanisms mediating antidepressant effects, there are several 
      efficient treatments. The anhedonia symptoms of depression are characterized by 
      decreased motivation and drive and imply possible malfunctioning of the 
      mesolimbic dopamine system, whereas cognitive deficits might reflect decreased 
      plasticity in hippocampus. In female Flinders Sensitive Line (FSL) rats, a model 
      of depression, we compared the effects of three long-term antidepressant 
      treatments: voluntary running, escitalopram and the combination of both on 
      antidepressant-like behaviour in the Porsolt swim test (PST), and on regulation 
      of mRNA for dopamine and neuropeptides in striatal dopamine pathways and 
      brain-derived neurotrophic factor (BDNF) in hippocampus. Escitalopram diet 
      attenuated running behaviour in FSL rats but not in non-depressed controls rats. 
      In the PST the running group had increased climbing activity 
      (noradrenergic/dopaminergic response), whereas the combination of escitalopram 
      and running-wheel access increased swimming (serotonergic response). Running 
      elevated mRNA for dynorphin in caudate putamen and BDNF in hippocampus. The 
      combined treatment down-regulated D1 receptor and enkephalin mRNA in accumbens. 
      Escitalopram alone did not affect behaviour or mRNA levels. We demonstrate a 
      novel behavioural effect of escitalopram, i.e. attenuation of running in 
      'depressed' rats. The antidepressant-like effect of escitalopram was dependent on 
      the presence of a running wheel, but not actual running indicating that the 
      environment influenced the antidepressant effect of escitalopram. Different 
      patterns of mRNA changes in hippocampus and brain reward pathways and responses 
      in the PST by running and escitalopram suggest that antidepressant-like responses 
      by running and escitalopram are achieved by different mechanisms.
FAU - Bjornebekk, Astrid
AU  - Bjornebekk A
AD  - Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
FAU - Mathe, Aleksander A
AU  - Mathe AA
FAU - Gruber, Susanne H M
AU  - Gruber SH
FAU - Brene, Stefan
AU  - Brene S
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080623
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Antidepressive Agents, Second-Generation)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0DHU5B8D6V (Citalopram)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents, Second-Generation/*pharmacology
MH  - Behavior, Animal/*drug effects
MH  - Body Weight/drug effects
MH  - Brain Chemistry/*drug effects
MH  - Citalopram/*pharmacology
MH  - Data Interpretation, Statistical
MH  - Diet
MH  - Eating/drug effects
MH  - Female
MH  - *Housing, Animal
MH  - In Situ Hybridization
MH  - Motor Activity/drug effects
MH  - Nerve Tissue Proteins/biosynthesis/genetics
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Swimming/psychology
EDAT- 2008/06/24 09:00
MHDA- 2009/01/27 09:00
CRDT- 2008/06/24 09:00
PHST- 2008/06/24 09:00 [pubmed]
PHST- 2009/01/27 09:00 [medline]
PHST- 2008/06/24 09:00 [entrez]
AID - S1461145708008912 [pii]
AID - 10.1017/S1461145708008912 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2008 Dec;11(8):1135-47. doi: 
      10.1017/S1461145708008912. Epub 2008 Jun 23.