PMID- 18570786
OWN - NLM
STAT- MEDLINE
DCOM- 20080915
LR  - 20080623
IS  - 1579-2242 (Electronic)
IS  - 0300-8932 (Linking)
VI  - 61
IP  - 6
DP  - 2008 Jun
TI  - [Diabetic and nondiabetic patients respond differently to transendocardial 
      injection of bone marrow mononuclear cells: findings from prospective clinical 
      trials in "no-option" patients].
PG  - 635-9
AB  - Whether stem cell treatment has the same effect in diabetics and nondiabetics is 
      unknown. To compare outcomes in these two groups, we analyzed data from 26 
      consecutive patients with chronic ischemic cardiomyopathy who were taking part in 
      two clinical trials. Revascularization was not an option for these patients and 
      they were treated with bone marrow mononuclear cells (BMMNCs). Patients underwent 
      NOGA electromechanical mapping to identify viable myocardium (i.e., with a 
      unipolar voltage > or = 6.9 mV), after which they received a mean of 28.5+/-4.7 x 
      10(6) BMMNCs. Patients were followed up at 6 months. In nondiabetics, there was a 
      significant decrease in endsystolic volume between baseline and 6-month 
      follow-up. In addition, New York Heart Association (NYHA) functional class 
      decreased significantly (P=.04) from 3.0 (1.75-3.0) to 1.0 (1.0-2.0), the 
      Canadian Cardiovascular Society angina score (CCSAS) improved significantly 
      (P=.04) from 3.0 (2.0-4.0) to 1.0 (1.0-1.5), and oxygen uptake increased 
      significantly (P=.04) from 16.4 (13.1-21.5) to 24.5 (17.3-29.2) ml/kg/min. These 
      changes were not observed in diabetic patients. This is the first clinical study 
      to show that BMMNC injection could have a smaller effect in diabetics.
FAU - Jimenez-Quevedo, Pilar
AU  - Jimenez-Quevedo P
AD  - Centro de Terapia Celular, Texas Heart Institute, St. Luke's Episcopal Hospital, 
      Houston, Texas, Estados Unidos.
FAU - Silva, Guillherme V
AU  - Silva GV
FAU - Sanz-Ruiz, Ricardo
AU  - Sanz-Ruiz R
FAU - Oliveira, Edie M
AU  - Oliveira EM
FAU - Fernandes, Marlos R
AU  - Fernandes MR
FAU - Angeli, Franca
AU  - Angeli F
FAU - Willerson, James T
AU  - Willerson JT
FAU - Dohmann, Hans F
AU  - Dohmann HF
FAU - Perin, Emerson C
AU  - Perin EC
LA  - spa
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - El efecto de la inyeccion transendocardica de celulas mononucleadas de medula 
      osea es diferente en pacientes diabeticos y en no diabeticos: hallazgos derivados 
      de estudios clinicos prospectivos en pacientes "sin opcion".
PL  - Spain
TA  - Rev Esp Cardiol
JT  - Revista espanola de cardiologia
JID - 0404277
SB  - IM
MH  - Aged
MH  - *Bone Marrow Transplantation/methods
MH  - Coronary Disease/*therapy
MH  - Diabetic Angiopathies/*therapy
MH  - Endocardium
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Injections
MH  - Male
MH  - Middle Aged
MH  - Monocytes
MH  - Prospective Studies
EDAT- 2008/06/24 09:00
MHDA- 2008/09/16 09:00
CRDT- 2008/06/24 09:00
PHST- 2008/06/24 09:00 [pubmed]
PHST- 2008/09/16 09:00 [medline]
PHST- 2008/06/24 09:00 [entrez]
AID - 13123070 [pii]
PST - ppublish
SO  - Rev Esp Cardiol. 2008 Jun;61(6):635-9.