PMID- 18571006
OWN - NLM
STAT- MEDLINE
DCOM- 20080815
LR  - 20080623
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 69
IP  - 6
DP  - 2008 Jun
TI  - KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease.
PG  - 349-53
LID - 10.1016/j.humimm.2008.04.005 [doi]
AB  - Vogt-Koyanagi-Harada (VKH) disease is a putative autoimmune ocular inflammatory 
      disease and is known to be associated with HLA-DR4 and -DR1 in Mestizos. We 
      examined the genes encoding KIR receptors and human leukocyte antigen (HLA) class 
      I ligands in patients with VKH disease and compared to published controls. We 
      found trends toward more group B KIR haplogroups (p=0.059), with more activating 
      KIR genes, in patients compared to controls. All putative activating KIR-HLA 
      combinations were more common in patients, and some inhibitory KIR-HLA 
      combinations were more common in controls, although the differences were not 
      statistically significant. The trends observed in this study are consistent with 
      those reported for other autoimmune diseases.
FAU - Levinson, Ralph D
AU  - Levinson RD
AD  - Ocular Inflammatory Disease Center, Jules Stein Eye Institute, David Geffen 
      School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, 
      CA.
FAU - Du, Zeying
AU  - Du Z
FAU - Luo, Lihui
AU  - Luo L
FAU - Holland, Gary N
AU  - Holland GN
FAU - Rao, Narsing A
AU  - Rao NA
FAU - Reed, Elaine F
AU  - Reed EF
FAU - Rajalingam, Raja
AU  - Rajalingam R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080509
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - California/ethnology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DR Antigens/analysis/*genetics
MH  - Haplotypes
MH  - Humans
MH  - *Indians, North American
MH  - Male
MH  - Protein Interaction Domains and Motifs/genetics/immunology
MH  - Receptors, KIR/*genetics
MH  - Uveomeningoencephalitic Syndrome/ethnology/*genetics
EDAT- 2008/06/24 09:00
MHDA- 2008/08/16 09:00
CRDT- 2008/06/24 09:00
PHST- 2008/03/06 00:00 [received]
PHST- 2008/04/04 00:00 [accepted]
PHST- 2008/06/24 09:00 [pubmed]
PHST- 2008/08/16 09:00 [medline]
PHST- 2008/06/24 09:00 [entrez]
AID - S0198-8859(08)00064-5 [pii]
AID - 10.1016/j.humimm.2008.04.005 [doi]
PST - ppublish
SO  - Hum Immunol. 2008 Jun;69(6):349-53. doi: 10.1016/j.humimm.2008.04.005. Epub 2008 
      May 9.