PMID- 18571007
OWN - NLM
STAT- MEDLINE
DCOM- 20080815
LR  - 20221207
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 69
IP  - 6
DP  - 2008 Jun
TI  - Association of human leukocyte antigen-DRB1 alleles with disease susceptibility 
      and severity of aplastic anemia in Korean patients.
PG  - 354-9
LID - 10.1016/j.humimm.2008.04.009 [doi]
AB  - Although association of human leukocyte antigen (HLA)-DR2 (DRB1*1501) with 
      susceptibility to aplastic anemia (AA) has been well documented in several 
      different ethnic groups, little is known about the protective role of HLA in this 
      disease. HLA-DRB1 alleles were analyzed in 109 Korean AA patients (26 nonsevere 
      and 83 severe) and 800 healthy controls. The frequency of DRB1*1501 was 
      significantly higher in AA patients compared with controls [33.0% vs 15.3%, 
      p=0.000004, p(c)=0.0001, odds ratio (OR)=2.74]. Nonsevere AA (30.8%, OR=2.47) and 
      severe AA patients (33.7%, OR=2.83) showed similar changes, and DRB1*1501 was 
      considered a susceptibility factor to AA in both forms of the disease. The 
      frequency of DRB1*1302 in total AA patients was not different from controls 
      (12.8% vs 17.9%), but it was significantly lower in severe AA compared with 
      nonsevere AA patients (6.0% vs 34.6%, p=0.0006, p(c)=0.02, OR=0.12). DRB1*1302 
      was considered a protective factor against severe AA. In Koreans, DRB1*1501 was 
      associated with disease susceptibility to AA and DRB1*1302 with protection 
      against the severe form of the disease.
FAU - Song, Eun Young
AU  - Song EY
AD  - Department of Laboratory Medicine, Konkuk University College of Medicine, Seoul, 
      Korea.
FAU - Park, Soyun
AU  - Park S
FAU - Lee, Dong Soon
AU  - Lee DS
FAU - Cho, Han Ik
AU  - Cho HI
FAU - Park, Myoung Hee
AU  - Park MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080516
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anemia, Aplastic/blood/*genetics/immunology/physiopathology
MH  - *Asian People
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DR Antigens/blood/*genetics/immunology
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Infant
MH  - Korea
MH  - Male
MH  - Middle Aged
MH  - Severity of Illness Index
EDAT- 2008/06/24 09:00
MHDA- 2008/08/16 09:00
CRDT- 2008/06/24 09:00
PHST- 2008/01/02 00:00 [received]
PHST- 2008/04/14 00:00 [revised]
PHST- 2008/04/21 00:00 [accepted]
PHST- 2008/06/24 09:00 [pubmed]
PHST- 2008/08/16 09:00 [medline]
PHST- 2008/06/24 09:00 [entrez]
AID - S0198-8859(08)00070-0 [pii]
AID - 10.1016/j.humimm.2008.04.009 [doi]
PST - ppublish
SO  - Hum Immunol. 2008 Jun;69(6):354-9. doi: 10.1016/j.humimm.2008.04.009. Epub 2008 
      May 16.