PMID- 18571077
OWN - NLM
STAT- MEDLINE
DCOM- 20080731
LR  - 20080623
IS  - 0886-3350 (Print)
IS  - 0886-3350 (Linking)
VI  - 34
IP  - 7
DP  - 2008 Jul
TI  - Risk for uveitis after laser in situ keratomileusis in patients positive for 
      human leukocyte antigen-B27.
PG  - 1110-3
LID - 10.1016/j.jcrs.2008.03.016 [doi]
AB  - PURPOSE: To assess the incidence of, risk for, and visual outcomes of acute 
      anterior uveitis (AAU) in human leukocyte antigen (HLA)-B27 positive patients who 
      had laser in situ keratomileusis (LASIK). SETTING: University-based center. 
      METHODS: This study comprised 46 eyes of 23 HLA-B27 positive patients with a 
      5-year follow-up. Data on episodes of uveitis were reviewed retrospectively and 
      the incidence rates calculated for LASIK and non-LASIK eyes. Kaplan-Meier 
      survival probabilities were calculated for uveitis occurring during the final 36 
      to 60 months of the study. Survival probabilities between LASIK and non-LASIK 
      eyes were compared. RESULTS: Twenty eyes (10 patients) had LASIK a mean of 36 
      months+/-2 (SD) after the diagnosis of HLA-B27. In the HLA-B27 positive patients, 
      the incidence rates of uveitis between eyes that had and eyes that did not have 
      LASIK were not significantly different. The incidence rates of uveitis after 
      LASIK did not differ significantly between eyes with and eyes without episodes of 
      uveitis before LASIK (P=.135). The probability of an eye having no episode of 
      uveitis in the fourth and fifth year of follow-up was not significantly different 
      between eyes that had LASIK and those that did not (P=.668). CONCLUSIONS: The 
      occurrence rate of post-LASIK AAU in the HLA-B27 positive population was not 
      higher than the general incidence in a similar HLA-B27 population without 
      previous LASIK. A previous episode of uveitis did not appear to increase the risk 
      for uveitis after LASIK in HLA-B27 positive patients.
FAU - Moshirfar, Majid
AU  - Moshirfar M
AD  - Department of Ophthalmology and Visual Sciences, University of Utah Health 
      Sciences Center, Salt Lake City, Utah 84132, USA. majid.moshirfar@hsc.utah.edu
FAU - Siddharthan, K S
AU  - Siddharthan KS
FAU - Meyer, Jay J
AU  - Meyer JJ
FAU - Espandar, Ladan
AU  - Espandar L
FAU - Wolsey, Darcy H
AU  - Wolsey DH
FAU - Vitale, Albert T
AU  - Vitale AT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cataract Refract Surg
JT  - Journal of cataract and refractive surgery
JID - 8604171
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Acute Disease
MH  - Follow-Up Studies
MH  - HLA-B27 Antigen/*immunology
MH  - Humans
MH  - Incidence
MH  - *Keratomileusis, Laser In Situ
MH  - Lasers, Excimer/*therapeutic use
MH  - Myopia/immunology/surgery
MH  - *Postoperative Complications
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Treatment Outcome
MH  - Uveitis, Anterior/epidemiology/*etiology/immunology
MH  - Visual Acuity
EDAT- 2008/06/24 09:00
MHDA- 2008/08/01 09:00
CRDT- 2008/06/24 09:00
PHST- 2007/06/25 00:00 [received]
PHST- 2008/03/11 00:00 [accepted]
PHST- 2008/06/24 09:00 [pubmed]
PHST- 2008/08/01 09:00 [medline]
PHST- 2008/06/24 09:00 [entrez]
AID - S0886-3350(08)00332-5 [pii]
AID - 10.1016/j.jcrs.2008.03.016 [doi]
PST - ppublish
SO  - J Cataract Refract Surg. 2008 Jul;34(7):1110-3. doi: 10.1016/j.jcrs.2008.03.016.