PMID- 18571629
OWN - NLM
STAT- MEDLINE
DCOM- 20090217
LR  - 20230921
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 64
IP  - 6
DP  - 2008 Sep 15
TI  - Serum brain-derived neurotrophic factor, depression, and antidepressant 
      medications: meta-analyses and implications.
PG  - 527-32
LID - 10.1016/j.biopsych.2008.05.005 [doi]
AB  - BACKGROUND: Converging lines of evidence implicate the neurotrophin brain-derived 
      neurotrophic factor (BDNF) in the pathophysiology of major depression. Recent 
      studies have begun to explore the relationship between serum BDNF and depression. 
      METHODS: We conducted meta-analyses of 11 studies examining differences in serum 
      BDNF content between depressed and nondepressed subjects (N = 748), and eight 
      studies comparing pre- and post-antidepressant treatment serum BDNF content (N = 
      220). RESULTS: The meta-analysis revealed strong evidence that BDNF levels were 
      lower in depressed subjects than healthy control subjects (p < 6.8 x 10(-8)). 
      Similarly, the second meta-analysis found significantly higher BDNF levels after 
      antidepressant treatment (p = .003). There was no evidence of publication bias in 
      the first (p = .376) or second (p = .571) meta-analysis and no evidence that 
      either meta-analysis was unduly influenced by any one study. CONCLUSIONS: These 
      findings provide strong evidence to suggest that serum BDNF levels are abnormally 
      low in patients suffering from major depressive disorder and that the BDNF levels 
      are elevated following a course of antidepressant treatment. Although the 
      relationship of our findings to pathophysiology of depression and the mechanism 
      of drug action remains to be determined, the measure may have potential use as a 
      biomarker for psychiatric disorders or as a predictor of antidepressant efficacy.
FAU - Sen, Srijan
AU  - Sen S
AD  - Department of Psychiatry, Yale University School of Medicine, Connecticut Mental 
      Health Center, New Haven, Connecticut 06519, USA.
FAU - Duman, Ronald
AU  - Duman R
FAU - Sanacora, Gerard
AU  - Sanacora G
LA  - eng
GR  - P01 MH025642/MH/NIMH NIH HHS/United States
GR  - K02 MH076222/MH/NIMH NIH HHS/United States
GR  - K02 MH076222-03/MH/NIMH NIH HHS/United States
GR  - R01 MH045481/MH/NIMH NIH HHS/United States
GR  - K02 MH076222-01/MH/NIMH NIH HHS/United States
GR  - MH025642/MH/NIMH NIH HHS/United States
GR  - MH045481/MH/NIMH NIH HHS/United States
GR  - R37 MH045481/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080624
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder, Major/*blood/*drug therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
PMC - PMC2597158
MID - NIHMS67769
EDAT- 2008/06/24 09:00
MHDA- 2009/02/20 09:00
PMCR- 2009/09/15
CRDT- 2008/06/24 09:00
PHST- 2008/03/31 00:00 [received]
PHST- 2008/04/30 00:00 [revised]
PHST- 2008/05/12 00:00 [accepted]
PHST- 2008/06/24 09:00 [pubmed]
PHST- 2009/02/20 09:00 [medline]
PHST- 2008/06/24 09:00 [entrez]
PHST- 2009/09/15 00:00 [pmc-release]
AID - S0006-3223(08)00579-9 [pii]
AID - 10.1016/j.biopsych.2008.05.005 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2008 Sep 15;64(6):527-32. doi: 10.1016/j.biopsych.2008.05.005. 
      Epub 2008 Jun 24.