PMID- 18571640
OWN - NLM
STAT- MEDLINE
DCOM- 20081015
LR  - 20181201
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 591
IP  - 1-3
DP  - 2008 Sep 4
TI  - Antiteratogenic effect of resveratrol in mice exposed in utero to 
      2,3,7,8-tetrachlorodibenzo-p-dioxin.
PG  - 280-3
LID - 10.1016/j.ejphar.2008.05.033 [doi]
AB  - The effect of resveratrol, an aryl hydrocarbon receptor antagonist, on the 
      teratogenicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was 
      investigated. Pregnant C57BL/6J mice were orally administered resveratrol (50 
      mg/kg) for 6 consecutive days, from gestational day (GD) 8 to GD13, followed by 
      an oral challenge with TCDD (14 mug/kg) on GD12. TCDD caused severe fetal 
      malformations including cleft palate (40.7%), renal pelvic dilatation (100%, mean 
      score 3.060), and ureteric dilatation (100%, mean score 3.210) and tortuosity 
      (95.1%). Resveratrol significantly reduced both the incidence of TCDD-induced 
      cleft palate to 18.4% and the degrees of renal pelvic and ureteric dilatations 
      caused by TCDD. The results suggest that pretreatment with resveratrol might 
      bring a beneficial outcome for reducing the incidence and severity of fetal 
      malformations caused by TCDD exposure in utero.
FAU - Jang, Ja Young
AU  - Jang JY
AD  - College of Veterinary Medicine and Research Institute of Veterinary Medicine, 
      Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.
FAU - Park, Dongsun
AU  - Park D
FAU - Shin, Sunhee
AU  - Shin S
FAU - Jeon, Jeong Hee
AU  - Jeon JH
FAU - Choi, Byong-Il
AU  - Choi BI
FAU - Joo, Seong Soo
AU  - Joo SS
FAU - Hwang, Seock-Yeon
AU  - Hwang SY
FAU - Nahm, Sang-Seop
AU  - Nahm SS
FAU - Kim, Yun-Bae
AU  - Kim YB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080528
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - 0 (Stilbenes)
RN  - 0 (Teratogens)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Abnormalities, Drug-Induced/etiology/physiopathology/*prevention & control
MH  - Administration, Oral
MH  - Animals
MH  - Cleft Palate/chemically induced/prevention & control
MH  - Dilatation, Pathologic/chemically induced/prevention & control
MH  - Female
MH  - Hydronephrosis/chemically induced/prevention & control
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Polychlorinated Dibenzodioxins/toxicity
MH  - Pregnancy
MH  - Receptors, Aryl Hydrocarbon/*antagonists & inhibitors
MH  - Resveratrol
MH  - Severity of Illness Index
MH  - Stilbenes/*pharmacology
MH  - Teratogens/*toxicity
EDAT- 2008/06/24 09:00
MHDA- 2008/10/16 09:00
CRDT- 2008/06/24 09:00
PHST- 2008/01/02 00:00 [received]
PHST- 2008/04/21 00:00 [revised]
PHST- 2008/05/20 00:00 [accepted]
PHST- 2008/06/24 09:00 [pubmed]
PHST- 2008/10/16 09:00 [medline]
PHST- 2008/06/24 09:00 [entrez]
AID - S0014-2999(08)00582-7 [pii]
AID - 10.1016/j.ejphar.2008.05.033 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2008 Sep 4;591(1-3):280-3. doi: 10.1016/j.ejphar.2008.05.033. 
      Epub 2008 May 28.