PMID- 18572328
OWN - NLM
STAT- MEDLINE
DCOM- 20090203
LR  - 20081105
IS  - 0344-0338 (Print)
IS  - 0344-0338 (Linking)
VI  - 204
IP  - 11
DP  - 2008
TI  - Hyperplastic intraparotid lymph nodes with incipient Warthin's tumor presenting 
      as a parotid tumor.
PG  - 863-6
LID - 10.1016/j.prp.2008.04.012 [doi]
AB  - Reactive follicular hyperplasia of the intraparotid lymph nodes (IPLs) forming a 
      parotid tumor has rarely been reported, and the pathogenesis of Warthin's tumor 
      has not been determined. A case of hyperplastic IPLs with incipient Warthin's 
      tumors presenting as a parotid tumor is presented. A 68-year-old Japanese patient 
      presented with a tumor of the right parotid gland, and the tumor was resected. 
      Pathologic examination showed seven hyperplastic IPLs (3-15 mm in diameter) with 
      follicular hyperplasia with a capsule, marginal sinuses, and high endothelial 
      venules. Very small foci of Warthin's tumor were recognized in two of the IPLs. 
      Non-tumorous ductules were scattered in four IPLs. Immunohistochemical studies 
      showed that the oncocytes of the small Warthin's tumor and the ductular elements 
      were positive for cytokeratin, but negative for carcinoembryonic antigen, 
      vimentin, alpha-smooth muscle antigen, and S100 protein. The ki-67 labeling was 
      3%. CD20-positive B lymphocytes were located in the germinal center and 
      peripheral B zone, and CD3-positive T lymphocytes in the interfollicular T zone. 
      The present case suggests that reactive hyperplastic IPLs may form a parotid 
      tumor, and that Warthin's tumor may develop in hyperplastic IPLs at the inception 
      of its tumorigenesis.
FAU - Terada, Tadashi
AU  - Terada T
AD  - Department of Pathology, Shizuoka Municipal Shimizu Hospital, Miyakami, Shizuoka, 
      Japan. piyo0111jp@yahoo.co.jp
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20080624
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
SB  - IM
MH  - Adenolymphoma/metabolism/*pathology
MH  - Aged
MH  - Diagnosis, Differential
MH  - Humans
MH  - Hyperplasia
MH  - Immunohistochemistry
MH  - Lymph Nodes/*pathology
MH  - Male
MH  - Parotid Gland/immunology/*pathology
MH  - Parotid Neoplasms/*pathology
EDAT- 2008/06/24 09:00
MHDA- 2009/02/04 09:00
CRDT- 2008/06/24 09:00
PHST- 2008/02/21 00:00 [received]
PHST- 2008/04/18 00:00 [revised]
PHST- 2008/04/18 00:00 [accepted]
PHST- 2008/06/24 09:00 [pubmed]
PHST- 2009/02/04 09:00 [medline]
PHST- 2008/06/24 09:00 [entrez]
AID - S0344-0338(08)00111-8 [pii]
AID - 10.1016/j.prp.2008.04.012 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2008;204(11):863-6. doi: 10.1016/j.prp.2008.04.012. Epub 2008 
      Jun 24.