PMID- 18573815
OWN - NLM
STAT- MEDLINE
DCOM- 20081231
LR  - 20180924
IS  - 1352-4585 (Print)
IS  - 1352-4585 (Linking)
VI  - 14
IP  - 8
DP  - 2008 Sep
TI  - EBNA-1 reactivity and HLA DRB1*1501 as statistically independent risk factors for 
      multiple sclerosis: a case-control study.
PG  - 1120-2
LID - 10.1177/1352458508092353 [doi]
AB  - OBJECTIVES AND METHODS: The interaction between the two best documented risk 
      factors (human leukocyte antigen [HLA] class II [DRB1*1501 positivity] and 
      Epstein-Barr virus [elevated Epstein-Barr nuclear antigen 1 (EBNA-1) antibody 
      reactivity]) for multiple sclerosis (MS) was studied in a case-control study of 
      biobank samples from 109 MS cases and 212 matched referents. RESULTS: 
      Multivariate logistic regression analysis showed that both were statistically 
      significant in both sexes. HLA DRB1*1501-positive referents had higher EBNA-1 
      reactivity than HLA-negative referents. Less EBNA-1 reactivity was required to 
      increase the MS risk in HLA DRB1*1501-positives than in HLA-negatives. 
      CONCLUSION: We suggest that HLA DRB1*1501-positive individuals have an increased 
      vulnerability to EBV-induced autoimmunity.
FAU - Sundstrom, P
AU  - Sundstrom P
AD  - Department of Neurology, Umea University Hospital, Umea, Sweden. 
      peter.sundstrom@neuro.umu.se
FAU - Nystrom, L
AU  - Nystrom L
FAU - Jidell, E
AU  - Jidell E
FAU - Hallmans, G
AU  - Hallmans G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080623
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (Epstein-Barr Virus Nuclear Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*15:01 antigen)
RN  - O5GA75RST7 (EBV-encoded nuclear antigen 1)
SB  - IM
MH  - Case-Control Studies
MH  - Epstein-Barr Virus Nuclear Antigens/*blood
MH  - HLA-DR Antigens/*blood
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - *Multiple Sclerosis/epidemiology/immunology/virology
MH  - Multivariate Analysis
MH  - Risk Factors
MH  - Sweden/epidemiology
EDAT- 2008/06/25 09:00
MHDA- 2009/01/01 09:00
CRDT- 2008/06/25 09:00
PHST- 2008/06/25 09:00 [pubmed]
PHST- 2009/01/01 09:00 [medline]
PHST- 2008/06/25 09:00 [entrez]
AID - 1352458508092353 [pii]
AID - 10.1177/1352458508092353 [doi]
PST - ppublish
SO  - Mult Scler. 2008 Sep;14(8):1120-2. doi: 10.1177/1352458508092353. Epub 2008 Jun 
      23.