PMID- 18573993
OWN - NLM
STAT- MEDLINE
DCOM- 20080812
LR  - 20170214
IS  - 0022-0345 (Print)
IS  - 0022-0345 (Linking)
VI  - 87
IP  - 7
DP  - 2008 Jul
TI  - MMP-3 response to compressive forces in vitro and in vivo.
PG  - 692-6
AB  - During orthodontic tooth movement, bone resorption occurs at the compression 
      site. However, the mechanism underlying resorption remains unclear. Applying 
      compressive force to human osteoblast-like cells grown in a 3D collagen gel, we 
      examined gene induction by using microarray and RT-PCR analysis. Among 43 genes 
      exhibiting significant changes, cyclo-oxygenase-2, ornithine decarboxylase, and 
      matrix metalloproteinase-3 (MMP-3) were up-regulated, whereas membrane-bound 
      interleukin-1 receptor accessory protein was down-regulated. The MMP-3 protein 
      increases were further confirmed by Western blot. To ascertain whether MMP-3 is 
      up-regulated in vivo by orthodontic force, we examined human bone samples at the 
      compressive site by realigning the angulated molars. Immunohistochemical staining 
      revealed MMP-3 distributed along the compressive site of the bony region within 3 
      days of compression. Since MMP-3 participates in degradation of a wide range of 
      extracellular matrix molecules, we propose that MMP-3 plays an important role in 
      bone resorption during orthodontic tooth movement.
FAU - Chang, H-H
AU  - Chang HH
AD  - School of Dentistry, National Taiwan University, Taiwan.
FAU - Wu, C-B
AU  - Wu CB
FAU - Chen, Y-J
AU  - Chen YJ
FAU - Weng, C-Y
AU  - Weng CY
FAU - Wong, W-P
AU  - Wong WP
FAU - Chen, Y-J
AU  - Chen YJ
FAU - Chang, B-E
AU  - Chang BE
FAU - Chen, M-H
AU  - Chen MH
FAU - Yao, C-C J
AU  - Yao CC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Dent Res
JT  - Journal of dental research
JID - 0354343
RN  - 0 (Gels)
RN  - 9007-34-5 (Collagen)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 1.14.99.1 (PTGS2 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 4.1.1.17 (Ornithine Decarboxylase)
SB  - IM
MH  - Adaptation, Physiological
MH  - Alveolar Process/*enzymology
MH  - Bone Remodeling/*physiology
MH  - Cell Culture Techniques
MH  - Cells, Cultured
MH  - Collagen
MH  - Cyclooxygenase 2/metabolism
MH  - Gels
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation
MH  - Humans
MH  - Matrix Metalloproteinase 3/*metabolism
MH  - Models, Biological
MH  - Oligonucleotide Array Sequence Analysis
MH  - Ornithine Decarboxylase/metabolism
MH  - Osteoblasts/cytology/*enzymology
MH  - Statistics, Nonparametric
MH  - *Tooth Movement Techniques
MH  - Transcriptional Activation
EDAT- 2008/06/25 09:00
MHDA- 2008/08/13 09:00
CRDT- 2008/06/25 09:00
PHST- 2008/06/25 09:00 [pubmed]
PHST- 2008/08/13 09:00 [medline]
PHST- 2008/06/25 09:00 [entrez]
AID - 87/7/692 [pii]
AID - 10.1177/154405910808700714 [doi]
PST - ppublish
SO  - J Dent Res. 2008 Jul;87(7):692-6. doi: 10.1177/154405910808700714.