PMID- 18577028 OWN - NLM STAT- MEDLINE DCOM- 20080725 LR - 20211020 IS - 1365-2249 (Electronic) IS - 0009-9104 (Print) IS - 0009-9104 (Linking) VI - 153 IP - 1 DP - 2008 Jul TI - Clinical immunology review series: an approach to the use of the immunology laboratory in the diagnosis of clinical allergy. PG - 10-8 LID - 10.1111/j.1365-2249.2008.03695.x [doi] AB - In the last 10 years UK immunology laboratories have seen a dramatic increase in the number and range of allergy tests performed. The reasons for this have been an increase in the incidence of immunoglobulin E (IgE)-mediated allergic disease set against a background of greater public awareness and more referrals for assessment. Laboratory testing forms an integral part of a comprehensive allergy service and physicians treating patients with allergic disease need to have an up-to-date knowledge of the range of tests available, their performance parameters and interpretation as well as the accreditation status of the laboratory to which tests are being sent. The aim of this review is to describe the role of the immunology laboratory in the assessment of patients with IgE-mediated allergic disease and provide an up-to-date summary of the tests currently available, their sensitivity, specificity, interpretation and areas of future development. FAU - Williams, P AU - Williams P AD - Department of Biochemistry and Immunology, University Hospital of Wales, Cardiff, UK. paule.williams@cardiffandvale.wales.nhs.uk FAU - Sewell, W A C AU - Sewell WA FAU - Bunn, C AU - Bunn C FAU - Pumphrey, R AU - Pumphrey R FAU - Read, G AU - Read G FAU - Jolles, S AU - Jolles S LA - eng PT - Journal Article PT - Review PL - England TA - Clin Exp Immunol JT - Clinical and experimental immunology JID - 0057202 RN - 0 (Allergens) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Allergens MH - Humans MH - Hypersensitivity/*diagnosis/immunology MH - Immunoglobulin E/blood MH - Immunologic Tests MH - Laboratories PMC - PMC2432092 EDAT- 2008/06/26 09:00 MHDA- 2008/07/26 09:00 PMCR- 2009/07/01 CRDT- 2008/06/26 09:00 PHST- 2008/06/26 09:00 [pubmed] PHST- 2008/07/26 09:00 [medline] PHST- 2008/06/26 09:00 [entrez] PHST- 2009/07/01 00:00 [pmc-release] AID - CEI3695 [pii] AID - 10.1111/j.1365-2249.2008.03695.x [doi] PST - ppublish SO - Clin Exp Immunol. 2008 Jul;153(1):10-8. doi: 10.1111/j.1365-2249.2008.03695.x.