PMID- 18577134
OWN - NLM
STAT- MEDLINE
DCOM- 20081003
LR  - 20211020
IS  - 1742-481X (Electronic)
IS  - 1742-4801 (Print)
IS  - 1742-4801 (Linking)
VI  - 5 Suppl 2
IP  - Suppl 2
DP  - 2008 Jun
TI  - The safety of negative pressure wound therapy using vacuum-assisted closure in 
      diabetic foot ulcers treated in the outpatient setting.
PG  - 17-22
LID - 10.1111/j.1742-481X.2008.00467.x [doi]
AB  - The purpose of this project was to evaluate the safety of negative pressure wound 
      therapy using the vacuum-assisted closure (V.A.C.) Therapy System (KCI, San 
      Antonio, TX) in diabetic foot ulcers (DFUs) among wound centre outpatients. We 
      defined events that could represent complications or adverse events (AEs) as a 
      result of treatment with the V.A.C., including symptoms of infection, pain, 
      bleeding and periwound skin breakdown. The frequency of these AEs among V.A.C. 
      patients with DFUs was compared with those among similar non V.A.C. patients. 
      This project prospectively queried data collected during routine clinical care 
      from 16 outpatient wound centres using the Intellicure electronic medical record 
      system. The electronic records were de-identified according to HIPAA requirements 
      and pooled to create a data repository dedicated to research (the Intellicure 
      Research Consortium). Analysis was performed on 1331 DFUs representing 16,438 
      outpatient visits. A total of 1299 non V.A.C. and 72 V.A.C. DFUs were available 
      for analysis. There was either no statistical difference between the AEs of 
      V.A.C. versus non V.A.C. patients or the V.A.C. exerted a protective effect. We 
      conclude that the V.A.C. is safe in outpatient use.
FAU - Fife, Caroline E
AU  - Fife CE
AD  - Department of Anesthesiology, The University of Texas Health Science Center, 
      Houston, TX 77030, USA. caroline.e.fife@uth.tmc.edu
FAU - Walker, David
AU  - Walker D
FAU - Thomson, Brett
AU  - Thomson B
FAU - Otto, Gordon
AU  - Otto G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int Wound J
JT  - International wound journal
JID - 101230907
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Ambulatory Care/*methods
MH  - Analysis of Variance
MH  - Chronic Disease
MH  - Comorbidity
MH  - Cross Infection/etiology
MH  - Diabetic Foot/epidemiology/etiology/*therapy
MH  - Hemorrhage/etiology
MH  - Humans
MH  - Linear Models
MH  - Medical Records Systems, Computerized
MH  - Middle Aged
MH  - Negative-Pressure Wound Therapy/adverse effects/*methods
MH  - Pain/etiology
MH  - Prospective Studies
MH  - Risk Factors
MH  - *Safety
MH  - Severity of Illness Index
MH  - Smoking/adverse effects
MH  - Texas/epidemiology
MH  - Treatment Outcome
MH  - *Wound Healing
PMC - PMC7951348
COIS- This project was funded by KCI. Both Caroline Fife and David Walker hold stock in 
      Intellicure and are major shareholders in Intellicure. Brett Thomson is a minor 
      shareholder in Intellicure. Gordon Otto has declare no conflicts of interest.
EDAT- 2008/07/17 09:00
MHDA- 2008/10/04 09:00
PMCR- 2008/06/10
CRDT- 2008/07/17 09:00
PHST- 2008/07/17 09:00 [pubmed]
PHST- 2008/10/04 09:00 [medline]
PHST- 2008/07/17 09:00 [entrez]
PHST- 2008/06/10 00:00 [pmc-release]
AID - IWJ467 [pii]
AID - 10.1111/j.1742-481X.2008.00467.x [doi]
PST - ppublish
SO  - Int Wound J. 2008 Jun;5 Suppl 2(Suppl 2):17-22. doi: 
      10.1111/j.1742-481X.2008.00467.x.