PMID- 18577292 OWN - NLM STAT- MEDLINE DCOM- 20090115 LR - 20211020 IS - 1469-7661 (Electronic) IS - 1355-6177 (Print) IS - 1355-6177 (Linking) VI - 14 IP - 4 DP - 2008 Jul TI - Neural substrates related to auditory working memory comparisons in dyslexia: an fMRI study. PG - 629-39 LID - 10.1017/S1355617708080867 [doi] AB - Adult readers with developmental phonological dyslexia exhibit significant difficulty comparing pseudowords and pure tones in auditory working memory (AWM). This suggests deficient AWM skills for adults diagnosed with dyslexia. Despite behavioral differences, it is unknown whether neural substrates of AWM differ between adults diagnosed with dyslexia and normal readers. Prior neuroimaging of adults diagnosed with dyslexia and normal readers, and post-mortem findings of neural structural anomalies in adults diagnosed with dyslexia support the hypothesis of atypical neural activity in temporoparietal and inferior frontal regions during AWM tasks in adults diagnosed with dyslexia. We used fMRI during two binaural AWM tasks (pseudowords or pure tones comparisons) in adults diagnosed with dyslexia (n = 11) and normal readers (n = 11). For both AWM tasks, adults diagnosed with dyslexia exhibited greater activity in left posterior superior temporal (BA 22) and inferior parietal regions (BA 40) than normal readers. Comparing neural activity between groups and between stimuli contrasts (pseudowords vs. tones), adults diagnosed with dyslexia showed greater primary auditory cortex activity (BA 42; tones > pseudowords) than normal readers. Thus, greater activity in primary auditory, posterior superior temporal, and inferior parietal cortices during linguistic and non-linguistic AWM tasks for adults diagnosed with dyslexia compared to normal readers indicate differences in neural substrates of AWM comparison tasks. FAU - Conway, Tim AU - Conway T AD - Department of Veterans Affairs Rehabilitation Research and Development Brain Rehabilitation Research Center of Excellence, Malcom Randall Veterans Administration Medical Center, Gainesville, Florida, USA. twc@phhp.ufl.edu FAU - Heilman, Kenneth M AU - Heilman KM FAU - Gopinath, Kaundinya AU - Gopinath K FAU - Peck, Kyung AU - Peck K FAU - Bauer, Russell AU - Bauer R FAU - Briggs, Richard W AU - Briggs RW FAU - Torgesen, Joseph K AU - Torgesen JK FAU - Crosson, Bruce AU - Crosson B LA - eng GR - P50 DC003888/DC/NIDCD NIH HHS/United States GR - R01 DC007387/DC/NIDCD NIH HHS/United States GR - P50 DC003888-040004/DC/NIDCD NIH HHS/United States GR - R01 HD030988/HD/NICHD NIH HHS/United States GR - HD30988/HD/NICHD NIH HHS/United States GR - R01 DC 007387/DC/NIDCD NIH HHS/United States GR - P50 DC 03888/DC/NIDCD NIH HHS/United States GR - R01 DC007387-03/DC/NIDCD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. PL - England TA - J Int Neuropsychol Soc JT - Journal of the International Neuropsychological Society : JINS JID - 9503760 SB - IM MH - Adult MH - Auditory Cortex/*physiopathology MH - Brain Mapping MH - Dominance, Cerebral/*physiology MH - Dyslexia/*physiopathology MH - Female MH - Humans MH - *Magnetic Resonance Imaging MH - Male MH - Memory, Short-Term/*physiology MH - Middle Aged MH - Parietal Lobe/*physiopathology MH - Pitch Perception/*physiology MH - Speech Perception/*physiology MH - Temporal Lobe/*physiopathology PMC - PMC3010865 MID - NIHMS246235 EDAT- 2008/06/26 09:00 MHDA- 2009/01/16 09:00 PMCR- 2010/12/28 CRDT- 2008/06/26 09:00 PHST- 2008/06/26 09:00 [pubmed] PHST- 2009/01/16 09:00 [medline] PHST- 2008/06/26 09:00 [entrez] PHST- 2010/12/28 00:00 [pmc-release] AID - S1355617708080867 [pii] AID - 10.1017/S1355617708080867 [doi] PST - ppublish SO - J Int Neuropsychol Soc. 2008 Jul;14(4):629-39. doi: 10.1017/S1355617708080867.