PMID- 18579335
OWN - NLM
STAT- MEDLINE
DCOM- 20081016
LR  - 20080901
IS  - 0741-8329 (Print)
IS  - 0741-8329 (Linking)
VI  - 42
IP  - 6
DP  - 2008 Sep
TI  - Serum TNF-alpha levels in relation to alcohol consumption and common TNF gene 
      polymorphisms.
PG  - 513-8
LID - 10.1016/j.alcohol.2008.04.008 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) mediates alcohol-induced organ 
      dysfunction, including alcoholic hepatitis. Variations in the TNF-alpha gene may 
      underlie the individual predisposition to alcoholic liver disease. Measurement of 
      serum TNF-alpha levels has become a routine in clinical practice. The study was 
      aimed at investigating the level of serum TNF-alpha levels in adults and 
      analyzing its relationship with different levels of alcohol consumption, as well 
      as the potential interaction between alcohol consumption and common TNF-alpha 
      gene polymorphisms in relation to TNF-alpha levels and liver disease. Serum 
      TNF-alpha was measured in a random sample of 459 individuals from a general adult 
      population and in 137 hospital-admitted alcoholics. Three common TNF-alpha gene 
      polymorphisms (-238G> A, -308G> A, and -857C> T) were investigated in 419 of 
      these individuals. In the general adult population, the TNF-alpha levels were 
      similar in alcohol abstainers and alcohol drinkers. Alcoholics admitted to the 
      hospital showed the highest TNF-alpha levels, which were correlated with liver 
      dysfunction. We found no evidence of an interaction between alcohol consumption 
      and TNF-alpha gene polymorphisms in relation to TNF-alpha levels. Carriers of the 
      TNF -238A allele tended to have a higher prevalence of advanced liver disease 
      than -238G homozygotes, confirming previous reports. In conclusion, 
      light-to-moderate drinking had no significant effect on the levels of serum 
      TNF-alpha levels. Serum TNF-alpha levels are elevated in alcoholics independently 
      of common TNF gene polymorphisms.
FAU - Gonzalez-Quintela, Arturo
AU  - Gonzalez-Quintela A
AD  - Department of Internal Medicine, Complejo Hospitalario Universitario de Santiago, 
      Santiago de Compostela, Spain. mearturo@usc.es
FAU - Campos, Joaquin
AU  - Campos J
FAU - Loidi, Lourdes
AU  - Loidi L
FAU - Quinteiro, Celsa
AU  - Quinteiro C
FAU - Perez, Luis-Fernando
AU  - Perez LF
FAU - Gude, Francisco
AU  - Gude F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080624
PL  - United States
TA  - Alcohol
JT  - Alcohol (Fayetteville, N.Y.)
JID - 8502311
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alcohol Drinking/*blood/genetics
MH  - Alcoholism/*blood/*genetics
MH  - Female
MH  - Humans
MH  - Liver Diseases, Alcoholic/blood/genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Tumor Necrosis Factor-alpha/*blood/*genetics
EDAT- 2008/06/27 09:00
MHDA- 2008/10/17 09:00
CRDT- 2008/06/27 09:00
PHST- 2007/10/22 00:00 [received]
PHST- 2008/04/25 00:00 [revised]
PHST- 2008/04/29 00:00 [accepted]
PHST- 2008/06/27 09:00 [pubmed]
PHST- 2008/10/17 09:00 [medline]
PHST- 2008/06/27 09:00 [entrez]
AID - S0741-8329(08)00217-6 [pii]
AID - 10.1016/j.alcohol.2008.04.008 [doi]
PST - ppublish
SO  - Alcohol. 2008 Sep;42(6):513-8. doi: 10.1016/j.alcohol.2008.04.008. Epub 2008 Jun 
      24.