PMID- 18579401
OWN - NLM
STAT- MEDLINE
DCOM- 20091019
LR  - 20181201
IS  - 1873-734X (Electronic)
IS  - 1010-7940 (Linking)
VI  - 34
IP  - 3
DP  - 2008 Sep
TI  - Heparin-induced thrombocytopenia and cardiopulmonary bypass: anticoagulation with 
      unfractionated heparin and the GPIIb/IIIa inhibitor tirofiban and successful use 
      of rFVIIa for post-protamine bleeding due to persistent platelet blockade.
PG  - 687-9
LID - 10.1016/j.ejcts.2008.05.029 [doi]
AB  - Heparin-induced thrombocytopenia was diagnosed in a 50-year-old man on day 5 
      after cardiac surgery (aorto-coronary bypass and mitral valve replacement). He 
      required redo (para-prosthesis leak) on day 13. The cardiopulmonary bypass (CPB) 
      was performed with unfractionated heparin (UFH) and the platelet glycoprotein 
      (GP) IIb/IIIa inhibitor tirofiban. Post-protamine bleeding likely due to 
      documented persistent platelet blockade by tirofiban was successfully treated 
      with one dose of recombinant activated factor VII (rFVIIa, 60 microg/kg). No 
      thrombotic complications were detected. The management of CPB with UHF and 
      tirofiban is a convenient option and rFVIIa seems appropriate to handle bleeding 
      issues.
FAU - Durand, Marion
AU  - Durand M
AD  - Inserm, U 734, Vandoeuvre-les-Nancy, France; Nancy-Universite Universite Henri 
      Poincare, Nancy, France.
FAU - Lecompte, Thomas
AU  - Lecompte T
FAU - Hacquard, Marie
AU  - Hacquard M
FAU - Carteaux, Jean-Pierre
AU  - Carteaux JP
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20080624
PL  - Germany
TA  - Eur J Cardiothorac Surg
JT  - European journal of cardio-thoracic surgery : official journal of the European 
      Association for Cardio-thoracic Surgery
JID - 8804069
RN  - 0 (Anticoagulants)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Platelet Glycoprotein GPIIb-IIIa Complex)
RN  - 42HK56048U (Tyrosine)
RN  - 9005-49-6 (Heparin)
RN  - EC 3.4.21.21 (Factor VIIa)
RN  - GGX234SI5H (Tirofiban)
SB  - IM
MH  - Anticoagulants/*adverse effects
MH  - Cardiopulmonary Bypass/methods
MH  - Drug Therapy, Combination
MH  - Factor VIIa/therapeutic use
MH  - Heparin/*adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Platelet Aggregation Inhibitors/*therapeutic use
MH  - Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors
MH  - Postoperative Complications
MH  - Postoperative Hemorrhage/drug therapy
MH  - Reoperation/methods
MH  - Thrombocytopenia/*chemically induced
MH  - Tirofiban
MH  - Tyrosine/*analogs & derivatives/therapeutic use
EDAT- 2008/06/27 09:00
MHDA- 2009/10/20 06:00
CRDT- 2008/06/27 09:00
PHST- 2007/09/24 00:00 [received]
PHST- 2008/03/25 00:00 [revised]
PHST- 2008/05/19 00:00 [accepted]
PHST- 2008/06/27 09:00 [pubmed]
PHST- 2009/10/20 06:00 [medline]
PHST- 2008/06/27 09:00 [entrez]
AID - S1010-7940(08)00580-0 [pii]
AID - 10.1016/j.ejcts.2008.05.029 [doi]
PST - ppublish
SO  - Eur J Cardiothorac Surg. 2008 Sep;34(3):687-9. doi: 10.1016/j.ejcts.2008.05.029. 
      Epub 2008 Jun 24.