PMID- 18579500
OWN - NLM
STAT- MEDLINE
DCOM- 20090505
LR  - 20191210
IS  - 1532-2114 (Electronic)
IS  - 1532-2114 (Linking)
VI  - 10
IP  - 1
DP  - 2009 Jan
TI  - Evaluation of left ventricular systolic and diastolic regional function after 
      enhanced external counter pulsation therapy using strain rate imaging.
PG  - 120-6
LID - 10.1093/ejechocard/jen183 [doi]
AB  - AIMS: Enhanced external counter pulsation (EECP) is a non-invasive and 
      non-pharmacological therapy for patients with symptomatic coronary artery disease 
      (CAD). There are, however, insufficient data to support the effectiveness of EECP 
      in improving the myocardial mechanical properties of patients with refractory 
      stable angina. We aimed to assess the effects of EECP on myocardial mechanical 
      properties and cardiac functions in CAD patients not eligible for surgical or 
      percutaneous revascularization procedures. METHODS AND RESULTS: Twenty patients 
      in New York Heart Association (NYHA) functional Class III and IV angina were 
      evaluated. The mean age of the patients was 63 +/- 9 years, and 65% were male. A 
      comprehensive echocardiographic study including an evaluation of the tissue 
      Doppler-based parameters of systolic and diastolic functions was performed before 
      and after the termination of the protocol. EECP was carried out 1 h per day, 5 
      days per week, for 7 weeks. EECP resulted in a significant increase in peak late 
      diastolic transmitral inflow velocity (0.75+/-0.14 vs. 0.83+/-0.20 m/s, P<0.05), 
      propagation velocity (42.35+/-6.25 vs. 46.00+/-5.68 cm/s, P<0.05), peak early 
      diastolic velocity of mitral annulus (5.35+/-1.79 vs. 5.95+/-1.10 cm/s, P<0.05), 
      peak systolic velocity (2.51+/-0.28 vs. 2.67+/-0.26, P<0.05), and early diastolic 
      velocity (3.24+/-0.18 vs. 3.52+/-0.26 cm/s, P<0.01) of all middle segments, peak 
      late diastolic velocity of all basal (4.48+/-0.58 vs. 4.75+/-0.70 cm/s, P<0.05) 
      and middle segments (2.82+/-0.66 vs. 3.25+/-0.46 cm/s, P<0.01), peak systolic 
      strain rate of all basal (0.76+/-0.07 vs. 0.99+/-0.08 1/s, P=0.001) and middle 
      segments (0.75+/-0.09 vs. 0.94+/-0.09 1/s, P<0.001), peak systolic strain of 
      basal (11.64+/-1.51 vs. 13.97+/-1.52%, P<0.01) and middle segments (11.81+/-1.15 
      vs.13.73+/-1.57%, P<0.001), and left ventricular (LV) ejection fraction 
      (40.25+/-12.72 vs. 46.25+/-12.97%, P<0.001).There was also a significant decrease 
      in the ratios of transmitral E/A (0.92+/-0.41 vs. 1.08+/-0.46, P<0.05) and E/Ea 
      (12.61+/-4.22 vs. 15.44+/-6.96, P<0.05) after EECP therapy. A significant 
      reduction in NYHA angina class (>or=1 angina class) was seen in the patients, who 
      completed treatment. CONCLUSION: EECP therapy seemed to improve both regional and 
      global LV systolic and diastolic functions in patients with chronic angina 
      pectoris.
FAU - Esmaeilzadeh, Maryam
AU  - Esmaeilzadeh M
AD  - Department of Echocardiography, Shaheed Rajaie Cardiovascular Medical and 
      Research Center, PO Box 1996911151, Vali-Asr Avenue, Adjacent to Mellat Park, 
      Tehran, Iran. m_eszadeh@yahoo.com
FAU - Khaledifar, Arsalan
AU  - Khaledifar A
FAU - Maleki, Majid
AU  - Maleki M
FAU - Sadeghpour, Anita
AU  - Sadeghpour A
FAU - Samiei, Niloufar
AU  - Samiei N
FAU - Moladoust, Hassan
AU  - Moladoust H
FAU - Noohi, Feridoun
AU  - Noohi F
FAU - Haghighi, Zahra Ojaghi
AU  - Haghighi ZO
FAU - Mohebbi, Ahmad
AU  - Mohebbi A
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080621
PL  - England
TA  - Eur J Echocardiogr
JT  - European journal of echocardiography : the journal of the Working Group on 
      Echocardiography of the European Society of Cardiology
JID - 100890618
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Angina Pectoris/*diagnostic imaging/*therapy
MH  - Blood Flow Velocity
MH  - Chronic Disease
MH  - Cohort Studies
MH  - Counterpulsation/*methods
MH  - Diastole/physiology
MH  - Echocardiography, Doppler/methods
MH  - Echocardiography, Doppler, Pulsed/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Probability
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Systole/physiology
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/physiopathology/*therapy
EDAT- 2008/06/27 09:00
MHDA- 2009/05/06 09:00
CRDT- 2008/06/27 09:00
PHST- 2008/06/27 09:00 [pubmed]
PHST- 2009/05/06 09:00 [medline]
PHST- 2008/06/27 09:00 [entrez]
AID - jen183 [pii]
AID - 10.1093/ejechocard/jen183 [doi]
PST - ppublish
SO  - Eur J Echocardiogr. 2009 Jan;10(1):120-6. doi: 10.1093/ejechocard/jen183. Epub 
      2008 Jun 21.