PMID- 18580325
OWN - NLM
STAT- MEDLINE
DCOM- 20080828
LR  - 20161124
IS  - 1538-7151 (Electronic)
IS  - 0277-1691 (Linking)
VI  - 27
IP  - 3
DP  - 2008 Jul
TI  - Alveolar rhabdomyosarcoma of the uterine cervix. A case report confirmed by FKHR 
      break-apart rearrangement using a fluorescence in situ hybridization probe on 
      paraffin-embedded tissues.
PG  - 442-6
LID - 10.1097/PGP.0b013e31816085ce [doi]
AB  - Alveolar rhabdomyosarcoma (ARMS) is a very rare malignant soft tissue tumor found 
      in the uterine cervix. In fact, to our knowledge, only 3 cases have previously 
      been described in the literature. A 49-year-old premenopausal woman who had a 
      history of vaginal bleeding underwent hysterectomy for multiple uterine nodules. 
      Pathologic examination showed multiple leiomyomas in the uterus and ARMS in the 
      cervix. An FKHR break-apart rearrangement by fluorescence in situ hybridization 
      (FISH) probe on paraffin-embedded tissues identified specific chromosomal 
      abnormalities. Systemic chemotherapy and pelvic irradiation were also performed. 
      She remains in clinical remission from neoplastic recurrences 14 months after 
      surgery. The literature has been reviewed; the histologic differential diagnosis 
      of this rare lesion has been discussed and FISH has been suggested to be useful 
      in differentiating ARMS from other poorly differentiated round cell tumors.
FAU - Rivasi, Francesco
AU  - Rivasi F
AD  - Department of Diagnostic Services, Laboratory and Forensic Medicine, Section of 
      Pathological Anatomy, University of Modena and Reggio Emilia, Modena, Italy. 
      rivasi@unimore.it
FAU - Botticelli, Laura
AU  - Botticelli L
FAU - Bettelli, Stefania Raffaella
AU  - Bettelli SR
FAU - Masellis, Giuseppe
AU  - Masellis G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Int J Gynecol Pathol
JT  - International journal of gynecological pathology : official journal of the 
      International Society of Gynecological Pathologists
JID - 8214845
RN  - 0 (FOXO1 protein, human)
RN  - 0 (Forkhead Box Protein O1)
RN  - 0 (Forkhead Transcription Factors)
SB  - IM
MH  - Female
MH  - Forkhead Box Protein O1
MH  - Forkhead Transcription Factors
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Middle Aged
MH  - Paraffin Embedding
MH  - Rhabdomyosarcoma, Alveolar/*pathology/therapy
MH  - Uterine Cervical Neoplasms/*pathology/therapy
EDAT- 2008/06/27 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/06/27 09:00
PHST- 2008/06/27 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/06/27 09:00 [entrez]
AID - 00004347-200807000-00019 [pii]
AID - 10.1097/PGP.0b013e31816085ce [doi]
PST - ppublish
SO  - Int J Gynecol Pathol. 2008 Jul;27(3):442-6. doi: 10.1097/PGP.0b013e31816085ce.